Luo Yuanyuan, Qu Hua, Wang Hang, Wei Huili, Wu Jing, Duan Yang, Liu Dan, Deng Huacong
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Mediators Inflamm. 2016;2016:6423637. doi: 10.1155/2016/6423637. Epub 2016 May 22.
The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P < 0.01). Patients with both OB and T2DM had the highest periostin levels. Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P < 0.05 or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P < 0.001). Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P < 0.001). These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels. Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.
本研究旨在探讨中国肥胖（OB）患者和2型糖尿病（T2DM）患者血浆骨膜蛋白、糖脂代谢、胰岛素抵抗和炎症之间的关系。T2DM组的血浆骨膜蛋白水平显著高于糖耐量正常（NGT）组（P<0.01）。同时患有OB和T2DM的患者骨膜蛋白水平最高。相关性分析显示，血浆骨膜蛋白水平与体重、腰围（WC）、体重指数（BMI）、腰臀比（WHR）、空腹血糖（FPG）、餐后2小时血糖（2h PG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、总胆固醇（TC）、空腹胰岛素（FINS）、胰岛素抵抗稳态模型评估（HOMA-IR）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）呈正相关（P<0.05或0.001），与高密度脂蛋白胆固醇（HDL-C）呈负相关（P<0.001）。多元线性回归分析显示，TG、TNF-α和HOMA-IR是影响血浆骨膜蛋白水平的独立相关因素（P<0.001）。这些结果表明，中国肥胖和T2DM患者的血浆骨膜蛋白水平显著更高。血浆骨膜蛋白水平与血浆TG、慢性炎症和胰岛素抵抗密切相关。
