Medical and Psychology School, Autonomous University of Baja California, Tijuana 22390, Baja California, Mexico.
Sports School, Autonomous University of Baja California, Tijuana 22390, Baja California, Mexico.
Int J Environ Res Public Health. 2023 Feb 25;20(5):4111. doi: 10.3390/ijerph20054111.
Chronic, low-grade inflammation in the elderly, usually known as inflammaging, accelerates the development of age-related diseases, including cancer, obesity, sarcopenia, and cardio-metabolic diseases. Two of the most studied interventions against inflammation are diet supplementation and the regular practice of exercise. The search for this systematic review was performed in Scopus, EBSCO, and PubMed databases within the last 10 years. Only randomized controlled trials that evaluated the effect of supplementation and exercise against inflammatory markers in older adults were included. After applying eligibility criteria and risk-of-bias assessment, 11 studies were included in the systematic review. In total, 638 participants were analyzed and the main supplements evaluated were amino acid or protein supplementation from different sources. In the counterpart, the exercise applied in the evaluations included strengthening exercises or aerobic training. The interventions had a range of duration between 4 and 24 weeks, and the effects on inflammation markers in most of the studies showed a decrease in pro-inflammatory cytokines and non- or slightly significant change in anti-inflammatory cytokines. However, these results suggest that exercise and supplement interventions can contribute to diminishing the inflammation process in the elderly. We can also conclude that further well-designed randomized controlled trials are needed to confirm the possible synergistic effects of exercise and food supplementation against inflammation in the elderly due to the limited studies that currently exist. This systematic review was registered in PROSPERO, ID CRD42023387184.
老年人慢性、低度炎症通常被称为炎症衰老，它加速了与年龄相关的疾病的发展，包括癌症、肥胖症、肌肉减少症和心血管代谢疾病。针对炎症的两种最受研究的干预措施是饮食补充和定期运动。本系统评价的检索在过去 10 年中在 Scopus、EBSCO 和 PubMed 数据库中进行。仅纳入了评估补充剂和运动对老年人炎症标志物影响的随机对照试验。在应用纳入和排除标准以及偏倚风险评估后，有 11 项研究纳入了系统评价。总共分析了 638 名参与者，评估的主要补充剂是来自不同来源的氨基酸或蛋白质补充剂。另一方面，评估中应用的运动包括力量训练或有氧运动。干预的持续时间范围为 4 至 24 周，大多数研究中炎症标志物的变化表明促炎细胞因子减少，抗炎细胞因子无明显变化或略有变化。然而，这些结果表明，运动和补充剂干预可以有助于减少老年人的炎症过程。我们还可以得出结论，由于目前存在的研究有限，需要进一步设计良好的随机对照试验来证实运动和食物补充对老年人炎症的可能协同作用。本系统评价已在 PROSPERO 注册，注册号为 CRD42023387184。
