Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France.
Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France.
Trends Neurosci. 2015 Sep;38(9):524-34. doi: 10.1016/j.tins.2015.07.008. Epub 2015 Aug 25.
In the neocortex, different types of excitatory and inhibitory neurons connect to one another following a detailed blueprint, defining functionally-distinct subnetworks, whose activity and modulation underlie complex cognitive functions. We review the cell-autonomous plasticity of perisomatic inhibition onto principal excitatory neurons. We propose that the tendency of different cortical layers to exhibit depression or potentiation of perisomatic inhibition is dictated by the specific identities of principal neurons (PNs). These are mainly defined by their projection targets and by their preference to be innervated by specific perisomatic-targeting basket cell types. Therefore, principal neurons responsible for relaying information to subcortical nuclei are differentially inhibited and show specific forms of plasticity compared to other PNs that are specialized in more associative functions.
在大脑皮层中，不同类型的兴奋性和抑制性神经元按照详细的蓝图相互连接，形成功能上不同的子网络，其活动和调制是复杂认知功能的基础。我们回顾了胞体抑制对主要兴奋性神经元的细胞自主可塑性。我们提出，不同皮层层表现出胞体抑制的压抑或增强的趋势是由主要神经元（PNs）的特定身份决定的。这些身份主要由它们的投射靶标和它们被特定的胞体靶向篮状细胞类型支配的倾向来定义。因此，负责将信息传递到皮质下核的主要神经元受到不同程度的抑制，并表现出与专门从事更关联功能的其他 PN 不同的可塑性形式。
