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皮质 PV 中间神经元对轴突自突触连接的强烈偏好有助于其调谐到 γ 振荡。

Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to γ-oscillations.

机构信息

ICM-Institut du Cerveau et de la Moelle épinière, Inserm U1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

出版信息

PLoS Biol. 2019 Sep 4;17(9):e3000419. doi: 10.1371/journal.pbio.3000419. eCollection 2019 Sep.

DOI:10.1371/journal.pbio.3000419
PMID:31483783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6726197/
Abstract

Parvalbumin (PV)-positive interneurons modulate cortical activity through highly specialized connectivity patterns onto excitatory pyramidal neurons (PNs) and other inhibitory cells. PV cells are autoconnected through powerful autapses, but the contribution of this form of fast disinhibition to cortical function is unknown. We found that autaptic transmission represents the most powerful inhibitory input of PV cells in neocortical layer V. Autaptic strength was greater than synaptic strength onto PNs as a result of a larger quantal size, whereas autaptic and heterosynaptic PV-PV synapses differed in the number of release sites. Overall, single-axon autaptic transmission contributed to approximately 40% of the global inhibition (mostly perisomatic) that PV interneurons received. The strength of autaptic transmission modulated the coupling of PV-cell firing with optogenetically induced γ-oscillations, preventing high-frequency bursts of spikes. Autaptic self-inhibition represents an exceptionally large and fast disinhibitory mechanism, favoring synchronization of PV-cell firing during cognitive-relevant cortical network activity.

摘要

钙结合蛋白（PV）阳性中间神经元通过高度特化的连接模式调节皮层活动，作用于兴奋性锥体神经元（PNs）和其他抑制性细胞。PV 细胞通过强大的自身突触进行自动连接，但这种快速抑制形式对皮层功能的贡献尚不清楚。我们发现，自身突触传递代表了新皮层 V 层中 PV 细胞最强大的抑制性输入。由于量子大小较大，自身突触的强度大于 PN 上的突触强度，而自身突触和异突触 PV-PV 突触在释放位点的数量上存在差异。总体而言，单轴突自身突触传递贡献了大约 40%的 PV 中间神经元接收的整体抑制（主要是胞体周围）。自身突触传递的强度调节了 PV 细胞放电与光遗传学诱导的γ-振荡的耦合，防止了尖峰的高频爆发。自身抑制代表了一种异常大和快速的去抑制机制，有利于在与认知相关的皮层网络活动中同步 PV 细胞的放电。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/0a33058b9d3d/pbio.3000419.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/8efbd456ff41/pbio.3000419.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/8bee2b45fc4e/pbio.3000419.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/d6ed7c4d5324/pbio.3000419.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/72fad2c14033/pbio.3000419.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/94883e9dd219/pbio.3000419.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/4ceb560fdcab/pbio.3000419.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/0a33058b9d3d/pbio.3000419.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/8efbd456ff41/pbio.3000419.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/8bee2b45fc4e/pbio.3000419.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/d6ed7c4d5324/pbio.3000419.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/72fad2c14033/pbio.3000419.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/94883e9dd219/pbio.3000419.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/4ceb560fdcab/pbio.3000419.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ea/6726197/0a33058b9d3d/pbio.3000419.g007.jpg

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