Ebrahimzadeh Attari Vahideh, Ostadrahimi Alireza, Asghari Jafarabadi Mohammad, Mehralizadeh Sajjad, Mahluji Sepideh
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Eur J Nutr. 2016 Sep;55(6):2129-36. doi: 10.1007/s00394-015-1027-6. Epub 2015 Aug 29.
The present randomized, double-blind, placebo-controlled study aimed to evaluate the effect of Zingiber officinale (ginger) consumption on some metabolic and clinical features of obesity.
Eighty eligible obese women (aged 18-45 years) were randomly assigned to either ginger or placebo groups (receiving 2 g/day of ginger powder or corn starch as two 1 g tablets) for 12 weeks. Body mass index (BMI) and body composition were assessed every 4 weeks, and serum levels of leptin, adiponectin, resistin, insulin and glucose were determined before and after intervention. The homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were also calculated.
Ginger consumption significantly decreased BMI, serum insulin and HOMA-IR index, along with increasing QUICKIs as compared to the placebo. Moreover, significant reductions in serum leptin, resistin and glucose were observed in both groups, especially in ginger group with nonsignificant differences between groups. The body composition and serum levels of adiponectin were not significantly changed in study groups.
In conclusion, our findings demonstrate a minor beneficial effect of 2 g ginger powder supplementation for 12 weeks on weight loss and some metabolic features of obesity. However, given the lack of data in this area, ongoing clinical trials are needed to further explore ginger's effectiveness.
本随机、双盲、安慰剂对照研究旨在评估食用姜对肥胖的某些代谢和临床特征的影响。
80名符合条件的肥胖女性（年龄18 - 45岁）被随机分为姜组或安慰剂组（每天服用2克姜粉或玉米淀粉，制成两片1克的片剂），为期12周。每4周评估一次体重指数（BMI）和身体成分，并在干预前后测定血清瘦素、脂联素、抵抗素、胰岛素和葡萄糖水平。还计算了胰岛素抵抗的稳态模型评估（HOMA - IR）和定量胰岛素敏感性检查指数（QUICKI）。
与安慰剂相比，食用姜显著降低了BMI、血清胰岛素和HOMA - IR指数，同时提高了QUICKI。此外，两组血清瘦素、抵抗素和葡萄糖均显著降低，尤其是姜组，组间差异无统计学意义。研究组的身体成分和血清脂联素水平无显著变化。
总之，我们的研究结果表明，连续12周补充2克姜粉对体重减轻和肥胖的一些代谢特征有轻微的有益作用。然而，鉴于该领域缺乏数据，需要进行正在进行的临床试验来进一步探索姜的有效性。
