Negri Roberto
Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro", Largo Donegani 2/3, I-28100 Novara, Italy.
Fitoterapia. 2015 Oct;106:92-109. doi: 10.1016/j.fitote.2015.08.011. Epub 2015 Aug 28.
Polyacetylenes are a class of polyketides related to fatty acids that occur in plants, fungi, marine organisms and animals. These compounds show a pleiotropic profile of bioactivity, that includes antitumor, antibacterial, antimicrobial or antifungal properties. Because of this, the literature on these compounds has grown exponentially, and this review aims at summarizing the inventory of polyacetylenes occurring in terrestrial eukaryotic organisms (plants and fungi) during the last 15 years, and at discussing progress in their bioactivities and in the identification of their biological targets.
聚乙炔是一类与脂肪酸相关的聚酮化合物，存在于植物、真菌、海洋生物和动物中。这些化合物具有多效性生物活性，包括抗肿瘤、抗菌、抗微生物或抗真菌特性。因此，关于这些化合物的文献呈指数级增长，本综述旨在总结过去15年中陆地真核生物（植物和真菌）中聚乙炔的清单，并讨论它们在生物活性以及生物靶点鉴定方面的进展。
