Liyanage Luckmini, Lee Nam Ju, Cook Tessa, Herrmann Howard C, Jagasia Dinesh, Litt Harold, Han Yuchi
Department of Biochemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Cardiovascular Division, Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Int J Cardiovasc Imaging. 2016 Jan;32(1):173-9. doi: 10.1007/s10554-015-0752-5. Epub 2015 Aug 29.
There is an established sex difference in cardiovascular disease among pre-menopausal women and age-matched men, with men having greater susceptibility to cardiovascular and coronary artery disease. Cardiovascular calcification may be linked to the atherosclerotic process and resulting disease, but the sex difference regarding coronary artery disease susceptibility and calcification is incompletely understood. We thought to measure calcium volume in different chest vascular beds in very elderly men and women with severe aortic stenosis (AS). Computed tomography scans of 94 patients with severe AS were calcium volume scored on Aquarius iNtuition Terarecon (Terarecon Inc., CA, USA) work stations. Coronary beds, aortic valve, mitral valve apparatus, and the thoracic aorta were examined. A significant sex difference in the mean total calcium volume of the coronary arteries was found in elderly (p = 0.001), with men having greater levels of calcification. There is also a significant sex difference in the amount of aortic valve calcium (p = 0.003). Furthermore, aortic and coronary calcification was independently correlated with sex. This study demonstrates a significant sex impact on calcification in the coronary beds and aortic valve in elderly patients with severe AS.
绝经前女性和年龄匹配的男性在心血管疾病方面存在既定的性别差异，男性更容易患心血管疾病和冠状动脉疾病。心血管钙化可能与动脉粥样硬化过程及由此引发的疾病有关，但关于冠状动脉疾病易感性和钙化的性别差异尚未完全明确。我们想测量患有严重主动脉瓣狭窄（AS）的高龄男性和女性不同胸部血管床的钙含量。对94例严重AS患者的计算机断层扫描在Aquarius iNtuition Terarecon（美国加利福尼亚州Terarecon公司）工作站上进行钙含量评分。检查冠状动脉床、主动脉瓣、二尖瓣装置和胸主动脉。在老年人中，冠状动脉平均总钙含量存在显著的性别差异（p = 0.001），男性的钙化程度更高。主动脉瓣钙含量也存在显著的性别差异（p = 0.003）。此外，主动脉和冠状动脉钙化与性别独立相关。本研究表明，性别对患有严重AS的老年患者冠状动脉床和主动脉瓣的钙化有显著影响。
