Han Yueh-Ying, Forno Erick, Brehm John M, Acosta-Pérez Edna, Alvarez María, Colón-Semidey Angel, Rivera-Soto Winna, Campos Hannia, Litonjua Augusto A, Alcorn John F, Canino Glorisa, Celedón Juan C
Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA.
Behavioral Sciences Research Institute and Department of Pediatrics, University of Puerto Rico, San Juan, PR.
Ann Allergy Asthma Immunol. 2015 Oct;115(4):288-293.e1. doi: 10.1016/j.anai.2015.07.020. Epub 2015 Aug 28.
Dietary patterns might influence the pathogenesis of asthma in Puerto Ricans, the ethnic group most affected by this disease in the United States.
To examine the association among diet, T-helper cell type 17 cytokines, and asthma in Puerto Rican children.
As part of a case-control study of 678 Puerto Rican children 6 to 14 years old in San Juan, participants completed a 75-item questionnaire on the child's food consumption in the prior week. Foods were aggregated into 7 groups: fruits, vegetables, grains, protein foods, dairy, fats, and sweets. Logistic regression was used to evaluate consumption frequency of each group, plasma T-helper cell type 17 cytokine levels, and asthma. Based on this analysis, a food score (range -2 [unhealthy diet: high consumption of dairy products and sweets, low consumption of vegetables and grains] to +2 [healthy diet: high consumption of grains and vegetables, low consumption of dairy and sweets]) was created to identify dietary patterns.
High consumption of grains was associated with lower odds of asthma (adjusted odds ratio [aOR] 0.52, 95% confidence interval [CI] 0.33-0.82), whereas frequent consumption of dairy products (aOR 1.93, 95% CI 1.32-2.84) or sweets (aOR 1.82, 95% CI 1.08-2.72) was associated with higher odds of asthma. A healthier diet (each 1-point increment in food score) was associated with lower levels of interleukin-17F (β = -1.48 pg/mL, 95% CI -1.78 to -1.20) and with 36% decreased odds of asthma (aOR 0.64, 95% CI 0.53-0.77).
A healthy diet, with frequent consumption of vegetables and grains and low consumption of dairy products and sweets, was associated with lower levels of interleulin-17F and decreased odds of childhood asthma in Puerto Ricans.
饮食模式可能会影响波多黎各人哮喘的发病机制，该族裔是美国受这种疾病影响最严重的族群。
研究波多黎各儿童饮食、17型辅助性T细胞细胞因子与哮喘之间的关联。
作为对圣胡安678名6至14岁波多黎各儿童进行的病例对照研究的一部分，参与者完成了一份关于孩子前一周食物消费情况的75项问卷。食物被汇总为7组：水果、蔬菜、谷物、蛋白质类食物、乳制品、脂肪和甜食。采用逻辑回归评估每组的消费频率、血浆17型辅助性T细胞细胞因子水平和哮喘情况。基于该分析，创建了一个食物评分（范围为-2 [不健康饮食：高乳制品和甜食消费，低蔬菜和谷物消费] 至 +2 [健康饮食：高谷物和蔬菜消费，低乳制品和甜食消费]）以确定饮食模式。
高谷物消费与较低的哮喘几率相关（调整后的优势比[aOR]为0.52，95%置信区间[CI]为0.33 - 0.82），而频繁食用乳制品（aOR 1.93，95% CI 1.32 - 2.84）或甜食（aOR 1.82，95% CI 1.08 - 2.72）与较高的哮喘几率相关。更健康的饮食（食物评分每增加1分）与白细胞介素-17F水平降低（β = -1.48 pg/mL，95% CI -1.78至-1.20）以及哮喘几率降低36%（aOR 0.64，95% CI 0.53 - 0.77）相关。
健康饮食，即频繁食用蔬菜和谷物且低消费乳制品和甜食，与波多黎各儿童白细胞介素-17F水平降低及儿童哮喘几率降低相关。
