Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Front Immunol. 2024 May 21;15:1383122. doi: 10.3389/fimmu.2024.1383122. eCollection 2024.
Presently, numerous studies have indicated that protein consumption and levels of blood albumin serve as important biomarkers for a range of respiratory illnesses. However, there have been few investigations into the correlation between protein consumption, serum albumin, and asthma.
Our analysis incorporated 2509 asthmatics from the 2011-2018 NHANES dataset. The investigation employed three linear regression models and XGBoost model to investigate the potential link between protein intake, serum albumin levels, and blood eosinophil counts (BEOC) in patients with asthma. The trend test, generalized additive model (GAM), and threshold effect model were utilized to validate this correlation. As well, we undertook stratified analyses to look at the correlation of serum albumin with BEOC among distinct populations.
In the univariable regression model, which did not account for any covariates, we observed a positive correlation between protein intake and BEOC. However, univariable and multivariable regression analyses all suggested a negative connection of serum albumin with BEOC in asthma populations. In Model C, which took into account all possible factors, BEOC dropped by 2.82 cells/uL for every unit increase in serum albumin (g/L). Additionally, the GAM and threshold effect model validated that serum albumin and BEOC showed an inverted U-shaped correlation.
Our investigation discovered there was no independent link between asthmatics' protein intake and BEOC. However, we observed an inverted U-shaped relationship between serum albumin levels and BEOC, suggesting a possible relationship between the overall nutritional status of asthmatics and immune system changes. Our findings provide new directions for future research in the field of asthma management and therapy.
目前，大量研究表明，蛋白质的摄入和血清白蛋白水平是多种呼吸系统疾病的重要生物标志物。然而，关于蛋白质摄入、血清白蛋白与哮喘之间的相关性研究较少。
我们分析了 2011-2018 年 NHANES 数据集内的 2509 例哮喘患者。研究采用三种线性回归模型和 XGBoost 模型，调查了哮喘患者的蛋白质摄入量、血清白蛋白水平和血嗜酸性粒细胞计数（BEOC）之间的潜在联系。趋势检验、广义加性模型（GAM）和阈值效应模型用于验证这种相关性。同时，我们进行了分层分析，以观察不同人群中血清白蛋白与 BEOC 的相关性。
在不考虑任何协变量的单变量回归模型中，我们观察到蛋白质摄入量与 BEOC 之间存在正相关。然而，单变量和多变量回归分析均表明，在哮喘人群中，血清白蛋白与 BEOC 呈负相关。在考虑了所有可能因素的模型 C 中，血清白蛋白每增加 1g/L，BEOC 减少 2.82 个细胞/uL。此外，GAM 和阈值效应模型验证了血清白蛋白和 BEOC 呈倒 U 型相关。
我们的研究发现哮喘患者的蛋白质摄入与 BEOC 之间没有独立的联系。然而，我们观察到血清白蛋白水平与 BEOC 之间呈倒 U 型关系，这表明哮喘患者的整体营养状况与免疫系统变化之间可能存在关联。我们的发现为哮喘管理和治疗领域的未来研究提供了新的方向。
