利用表观遗传数据预测染色体的空间组织。
Predicting the spatial organization of chromosomes using epigenetic data.
作者信息
Mourad Raphaël, Cuvier Olivier
机构信息
Laboratory of Molecular Biology of Eukaryotes (LBME), CNRS - University of Toulouse (UPS), F-31000, Toulouse, France.
出版信息
Genome Biol. 2015 Aug 29;16(1):182. doi: 10.1186/s13059-015-0752-8.
Abstract
Chromosome folding can reinforce the demarcation between euchromatin and heterochromatin. Two new studies show how epigenetic data, including DNA methylation, can accurately predict chromosome folding in three dimensions. Such computational approaches reinforce the idea of a linkage between epigenetically marked chromatin domains and their segregation into distinct compartments at the megabase scale or topological domains at a higher resolution. Please see related articles: http://dx.doi.org/10.1186/s13059-015-0741-y and http://dx.doi.org/10.1186/s13059-015-0740-z.
摘要
染色体折叠可加强常染色质与异染色质之间的界限。两项新研究展示了包括DNA甲基化在内的表观遗传数据如何能够准确预测三维染色体折叠。此类计算方法强化了这样一种观点，即表观遗传标记的染色质结构域之间存在联系，且它们在兆碱基尺度上会分离成不同的区室，或者在更高分辨率下分离成拓扑结构域。请参阅相关文章：http://dx.doi.org/10.1186/s13059-015-0741-y和http://dx.doi.org/10.1186/s13059-015-0740-z。
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