中风与癌症——复杂的关系。
Stroke and Cancer- A Complicated Relationship.
作者信息
Dearborn Jennifer L, Urrutia Victor C, Zeiler Steven R
出版信息
J Neurol Transl Neurosci. 2014;2(1):1039.
Abstract
The interrelationship between stroke and cancer is complex. Cancer and stroke may occur independently in a given patient, or cancer may directly or indirectly lead to stroke via: hypercoaguability, non-bacterial thrombotic endocarditis (NBTE), direct tumor compression of blood vessels, or treatment-related effects which potentiate stroke. Patients with cryptogenic stroke are relatively common, and under the right circumstances, may provide an opportunity to screen for occult malignancy. In this review, we discuss relevant data linking stroke and cancer as well as propose a testable algorithm for cancer screening in the patient with cryptogenic stroke. Future directions should focus on validating patient-care algorithms in prospective clinical trials to provide an evidence base for this important issue.
摘要
中风与癌症之间的相互关系很复杂。在特定患者中，癌症和中风可能独立发生，或者癌症可能通过以下方式直接或间接导致中风：高凝状态、非细菌性血栓性心内膜炎（NBTE）、肿瘤直接压迫血管或与治疗相关的影响（这些影响会增加中风风险）。隐源性中风患者相对常见，在适当情况下，可能为筛查隐匿性恶性肿瘤提供机会。在本综述中，我们讨论了将中风与癌症联系起来的相关数据，并提出了一种可用于对隐源性中风患者进行癌症筛查的可测试算法。未来的方向应集中在前瞻性临床试验中验证患者护理算法，以为这一重要问题提供证据基础。
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本文引用的文献
1
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J Stroke Cerebrovasc Dis. 2014 Apr;23(4):e249-54. doi: 10.1016/j.jstrokecerebrovasdis.2013.10.022. Epub 2013 Dec 2.
2
Ischemic stroke in patients with solid gynecologic tract tumors and coagulopathy.实体妇科肿瘤合并凝血功能障碍患者的缺血性脑卒中。
Eur Neurol. 2013;70(5-6):304-7. doi: 10.1159/000353799. Epub 2013 Sep 24.
3
Stroke and cancer: the importance of cancer-associated hypercoagulation as a possible stroke etiology.中风和癌症：癌症相关的高凝状态作为可能的中风病因的重要性。
Stroke. 2012 Nov;43(11):3029-34. doi: 10.1161/STROKEAHA.112.658625. Epub 2012 Sep 20.
4
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Expert Rev Hematol. 2012 Apr;5(2):201-9. doi: 10.1586/ehm.11.86.
5
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6
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7
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9
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Stroke. 2011 Sep;42(9):2410-8. doi: 10.1161/STROKEAHA.111.615203. Epub 2011 Aug 4.
10
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