Li Ya-mei, Du Zhi-min
Zhongguo Zhong Yao Za Zhi. 2015 May;40(9):1644-8.
Traditional Chinese medicine (TCM) has a good reputation for preventing or healing diseases in clinic due to its higher efficacy, minor toxicity and abundant resources. Screening bioactive components in TCMs is not only crucial for clarifying their action mechanisms, but also the basis of their safety and quality control. TCM is characterized by multiple components, multiple targets and multiple mechanisms, however the complex composition of TCM makes it difficult to study the therapeutic material basis which has become the bottleneck in the process of its modernization and internationalization. Recently, with the rapid development of modern technologies and the unceasing progress of various disciplines, multidisciplinary approach, such as analytical chemistry, chemistry of TCM, pharmacology, cell biology, systems biology and bioinformatics has been successfully applied to the study of TCM. Multidisciplinary approach realizes the communication and interaction of multi-discipline, and accelerates the research and development of TCM. This review summarizes the application of multidisciplinary approach which may have certain potential of bringing new thoughts to TCM research and provide references for screening and identification of therapeutic material basis of TCMs.
传统中药（TCM）因其疗效高、毒性小、资源丰富，在临床预防或治疗疾病方面享有良好声誉。筛选中药中的生物活性成分不仅对阐明其作用机制至关重要，也是其安全性和质量控制的基础。中药具有多成分、多靶点、多机制的特点，然而中药复杂的成分使其难以研究治疗物质基础，这已成为其现代化和国际化进程中的瓶颈。近年来，随着现代技术的快速发展和各学科的不断进步，多学科方法，如分析化学、中药化学、药理学、细胞生物学、系统生物学和生物信息学已成功应用于中药研究。多学科方法实现了多学科之间的交流与互动，加速了中药的研发。本文综述了多学科方法的应用，该方法可能为中药研究带来新的思路，并为中药治疗物质基础的筛选和鉴定提供参考。
