Yang Guang, Zhang Wenqi, Yu Chunlei, Ren Jin, An Zhe
Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
J Cancer Res Ther. 2015 Aug;11 Suppl 1:C1-6. doi: 10.4103/0973-1482.163830.
Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) are highly evolutionarily conserved noncoding small RNAs, which were first identified in Caenorhabditis elegans. There are 1100 or more miRNAs have been identified in Homo sapiens. Let-7 miRNA is involved in the regulation of gene expression in cells. Several novel factors and feedback loops involved in the regulation of the synthesis of let-7 have been identified and additional let-7 target genes have been found. Let-7 has also been shown to be significantly correlated with the occurrence and development of cancer and the results of preliminary studies suggest that it is involved in the regulation of oncogenic pathways in numerous types of tumors, such as, LC. As let-7 is a potential molecular target for tumor therapy, a mass of studies have been conducted focus on the relationship between let-7 and LC. With the mechanism becoming revealed, more and more groups are looking for the anti-tumor role of let-7 family in anti-tumor therapy development. In this review, we summarize the newest investigations on let-7 and LC, the regulation of let-7 and its targets gene have been discussed, and the attempts for new therapy for LC have also been summarized.
肺癌（LC）是全球癌症相关死亡的主要原因。微小RNA（miRNA）是高度进化保守的非编码小RNA，最初在秀丽隐杆线虫中被发现。在人类中已鉴定出1100种或更多的miRNA。Let-7 miRNA参与细胞中基因表达的调控。已经鉴定出几种参与Let-7合成调控的新因子和反馈环，并发现了更多Let-7靶基因。Let-7也已被证明与癌症的发生和发展显著相关，初步研究结果表明它参与了多种类型肿瘤（如LC）致癌途径的调控。由于Let-7是肿瘤治疗的潜在分子靶点，大量研究聚焦于Let-7与LC之间的关系。随着机制逐渐被揭示，越来越多的团队在抗肿瘤治疗开发中寻找Let-7家族的抗肿瘤作用。在本综述中，我们总结了关于Let-7和LC的最新研究，讨论了Let-7及其靶基因的调控，并总结了针对LC的新治疗尝试。
