Zheng Miaobing, Rangan Anna, Allman-Farinelli Margaret, Rohde Jeanett Friis, Olsen Nanna Julie, Heitmann Berit Lilienthal
1School of Molecular Bioscience,Charles Perkins Centre,University of Sydney,Sydney,NSW 2006,Australia.
2Research Unit for Dietary Studies,Institute of Preventive Medicine,Bispebjerg and Frederiksberg Hospitals,The Capital Region,2400 Copenhagen,Denmark.
Br J Nutr. 2015 Nov 14;114(9):1448-55. doi: 10.1017/S0007114515002974. Epub 2015 Sep 2.
The aim of the present study was to examine the associations of sugary drink consumption and its substitution with alternative beverages with body weight gain among young children predisposed to future weight gain. Secondary analysis of the Healthy Start Study, a 1·5-year randomised controlled trial designed to prevent overweight among Danish children aged 2-6 years (n 366), was carried out. Multivariate linear regression models were used to investigate the associations of beverage consumption with change in body weight (Δweight) or BMI(ΔBMI) z-score. Substitution models were used to extrapolate the influence of replacing sugary drinks with alternative beverages (water, milk and diet drinks) on Δweight or ΔBMI z-score. Sugary drink intake at baseline and substitution of sugary drinks with milk were associated with both Δweight and ΔBMI z-score. Every 100 g/d increase in sugary drink intake was associated with 0·10 kg and 0·06 unit increases in body weight (P=0·048) and BMI z-score (P=0·04), respectively. Substitution of 100 g/d sugary drinks with 100 g/d milk was inversely associated with Δweight (β=-0·16 kg; P=0·045) and ΔBMI z-score (β=-0·07 units; P=0·04). The results of this study suggest that sugary drink consumption was associated with body weight gain among young children with high predisposition for future overweight. In line with the current recommendations, sugary drinks, whether high in added or natural sugar, should be discouraged to help prevent childhood obesity. Milk may be a good alternative to sugary drinks with regard to weight management among young obesity-predisposed children.
本研究的目的是在易发生未来体重增加的幼儿中，考察含糖饮料消费及其被替代饮料替代与体重增加之间的关联。对“健康开端研究”进行了二次分析，该研究是一项为期1.5年的随机对照试验，旨在预防丹麦2至6岁儿童（n = 366）超重。使用多变量线性回归模型来研究饮料消费与体重变化（Δ体重）或BMI（ΔBMI）z评分之间的关联。使用替代模型来推断用替代饮料（水、牛奶和无糖饮料）替代含糖饮料对Δ体重或ΔBMI z评分的影响。基线时的含糖饮料摄入量以及用牛奶替代含糖饮料均与Δ体重和ΔBMI z评分相关。含糖饮料摄入量每增加100 g/d，体重分别增加0.10 kg（P = 0.048）和BMI z评分增加0.06单位（P = 0.04）。用100 g/d牛奶替代100 g/d含糖饮料与Δ体重（β = -0.16 kg；P = 0.045）和ΔBMI z评分（β = -0.07单位；P = 0.04）呈负相关。本研究结果表明，在未来超重易感性高的幼儿中，含糖饮料消费与体重增加有关。根据当前建议，应不鼓励饮用含糖饮料，无论其添加糖或天然糖含量高，以帮助预防儿童肥胖。就肥胖易感性高的幼儿体重管理而言，牛奶可能是含糖饮料的良好替代品。
