Kim Kye S, Lee Dongwon, Song Chul Gyu, Kang Peter M
Cardiovascular Institute, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA 02215, USA.
Department of Polymer Nano Science & Technology, Chonbuk National University, Jeonju, Chonbuk 561-756, South Korea.
Nanomedicine (Lond). 2015;10(17):2709-23. doi: 10.2217/nnm.15.108. Epub 2015 Sep 2.
Reactive oxygen species (ROS) are generated from the endogenous oxidative metabolism or from exogenous pro-oxidant exposure. Oxidative stress occurs when there is excessive production of ROS, outweighing the antioxidant defense mechanisms which may lead to disease states. Hydrogen peroxide (H2O2) is one of the most abundant and stable forms of ROS, implicated in inflammation, cellular dysfunction and apoptosis, which ultimately lead to tissue and organ damage. This review is an overview of the role of ROS in different diseases. We will also examine ROS-activated nanomaterials with emphasis on hydrogen peroxide, and their potential medical implications. Further development of the biocompatible, stimuli-activated agent responding to disease causing oxidative stress, may lead to a promising clinical use.
活性氧（ROS）由内源性氧化代谢或外源性促氧化剂暴露产生。当ROS产生过多，超过抗氧化防御机制时，就会发生氧化应激，这可能导致疾病状态。过氧化氢（H2O2）是最丰富、最稳定的ROS形式之一，与炎症、细胞功能障碍和细胞凋亡有关，最终导致组织和器官损伤。本综述概述了ROS在不同疾病中的作用。我们还将重点研究过氧化氢相关的ROS激活纳米材料及其潜在的医学意义。对引起疾病的氧化应激做出反应的生物相容性、刺激激活剂的进一步开发，可能会带来有前景的临床应用。
