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Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60.

作者信息

Li Jiansong, Zhang Shaoyong, Zhang Hui, Wang Haiyan, Zhang Ji, Chen Anliang, Wang Jidong, Xiang Wensheng

机构信息

Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin, China.

Provincial Joint Engineering Laboratory of Biopesticide Preparation, School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University, Lin'An, China.

出版信息

J Antibiot (Tokyo). 2017 Mar;70(3):297-300. doi: 10.1038/ja.2016.130. Epub 2016 Oct 26.

DOI:10.1038/ja.2016.130
PMID:27780966
Abstract
摘要

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Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase.通过阿维菌素聚酮合酶的结构域交换设计生物合成具有增强杀虫活性的25-甲基和25-乙基伊维菌素。
Microb Cell Fact. 2015 Sep 24;14:152. doi: 10.1186/s12934-015-0337-y.
3
Three new milbemycins from a genetically engineered strain S. avermitilis MHJ1011.
从基因工程菌株阿维链霉菌MHJ1011中分离得到的三种新米尔倍霉素。
J Antibiot (Tokyo). 2016 Feb;69(2):104-7. doi: 10.1038/ja.2015.90. Epub 2015 Sep 2.
4
Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities.通过基因替换生成具有增强杀螨和杀线虫活性的新型阿维菌素衍生物
Appl Environ Microbiol. 2015 Aug 15;81(16):5326-34. doi: 10.1128/AEM.01025-15. Epub 2015 May 29.
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Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis.从链霉菌bingchenggensis 出发，通过等离子体诱变与基因工程相结合的方法，得到以 5-氧代米尔贝霉素 A3/A4 为主成分的物质。
Appl Microbiol Biotechnol. 2014 Dec;98(23):9703-12. doi: 10.1007/s00253-014-5970-6. Epub 2014 Aug 2.
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Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains.驱虫阿维菌素类药物能杀死结核分枝杆菌，包括耐多药的临床分离株。
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Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells.米贝霉素化合物对阿霉素耐药人乳腺癌（MCF-7/adr）细胞中 P-糖蛋白介导的多药耐药的体外逆转作用。
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