维生素D缺乏与贫血风险：观察性研究的荟萃分析

Vitamin D deficiency and the risk of anemia: a meta-analysis of observational studies.

作者信息

Liu Taisheng, Zhong Shuling, Liu Luhao, Liu Shenghua, Li Xiaoning, Zhou Tianjun, Zhang Jinye

机构信息

a Department of Esophagus, Mediastinal Oncosurgery , Cancer Center of Guangzhou Medical University , Guangzhou , China .

b Department of Pediatrics , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China .

出版信息

Ren Fail. 2015 Jul;37(6):929-34. doi: 10.3109/0886022X.2015.1052979. Epub 2015 Sep 2.

DOI:10.3109/0886022X.2015.1052979

PMID:26329387

Abstract

AIMS

Anemia and vitamin D deficiency (VDD) are both very important health issues, recent accumulating evidence shows that VDD is prevalent in individuals with anemia. This meta-analysis aimed to detect a relationship between VDD and anemia.

METHODS

We identified eligible studies by searching the Pub Med, Embase and Cochrane Library before October 2014. Quality assessments were performed with the Newcastle-Ottawa Scale. Heterogeneity was evaluated by Cochran's Q test and source of heterogeneity was detected by subgroup analysis and sensitivity analysis.

RESULTS

A total of seven studies involving 5183 participants were included in the meta-analysis. VDD was associated with an increased incidence of anemia (OR = 2.25, 95% CI = 1.47-3.44), with significant evidence of heterogeneity among these studies (p for heterogeneity < 0.001, I(2) = 84.0%). The subgroup and sensitivity analysis confirmed the stability of the results and no publication bias was detected.

CONCLUSION

Our outcomes showed that VDD increased the risk of developing anemia. More researches are warranted to clarify an understanding of the association between VDD and risk of anemia.

摘要