Mackie Susan, Winkelman John W
Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Sleep Disorders Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square, 9th floor, Boston, MA 02114, USA; Sleep Disorders Clinical Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square, 9th floor, Boston, MA 02114, USA.
Sleep Med Clin. 2015 Sep;10(3):351-7, xv. doi: 10.1016/j.jsmc.2015.05.009. Epub 2015 Jun 27.
There are strong epidemiologic ties between restless legs syndrome (RLS) and a wide array of psychiatric conditions. Although the mechanism of this association is not fully understood, there are likely bidirectional cause-and-effect relationships. Appreciation of psychiatric comorbidity is an essential component of the treatment of RLS. Clinicians should be prepared to facilitate appropriate psychiatric treatment and consider the complex interactions between psychiatric medications, RLS medications, and the clinical course of both illnesses.
不宁腿综合征（RLS）与多种精神疾病之间存在密切的流行病学关联。尽管这种关联的机制尚未完全明确，但可能存在双向的因果关系。认识到精神疾病共病是RLS治疗的重要组成部分。临床医生应做好准备，促进适当的精神疾病治疗，并考虑精神科药物、RLS药物以及两种疾病临床病程之间的复杂相互作用。
