Hajivalili Mahsa, Pourgholi Fatemeh, Kafil Hossein Samadi, Jadidi-Niaragh Farhad, Yousefi Mehdi
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Curr Stem Cell Res Ther. 2016;11(1):41-50. doi: 10.2174/1574888x10666150902095031.
Amyotrophic lateral sclerosis (ALS is a neurodegenerative disorder which is characterized by motor neuron (MN dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其特征为运动神经元（MN）功能障碍、进行性麻痹和死亡。尽管已经采用了多种治疗方法来治疗ALS，但成效甚微。间充质干细胞（MSCs）等天然载体可能是解决治疗难题的一种有前景的工具。MSCs具有多能特性，如能够分化为多种细胞类型、易于获取、免疫调节、组织修复、分泌营养因子、分泌外泌体以及高效归巢。在本综述中，我们将讨论MSCs的特性及其在ALS患者中的可能治疗机制。
