Zhang Guan-ya, Nie Shao-ping, Huang Xiao-jun, Hu Jie-lun, Cui Steve W, Xie Ming-yong, Phillips Glyn O
State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, People's Republic of China.
Guelph Food Research Centre, Agriculture and Agri-Food Canada , 93 Stone Road West, Guelph, Ontario N1G 5C9, Canada.
J Agric Food Chem. 2016 Mar 30;64(12):2485-91. doi: 10.1021/acs.jafc.5b03117. Epub 2015 Sep 15.
This research was aimed to study the effect of Dendrobium officinale polysaccharide (Dendronan) on colonic health. Mice were fed Dendronan at doses of 40, 80, and 160 mg/kg body weight for 0, 10, 20, and 30 days, respectively. Results showed that Dendronan, which has a special structure formed by mannose and glucose, rich in O-acetyl groups, exhibited improving effects on colonic and fecal parameters of Balb/c mice. After Dendronan feeding, the content of short-chain fatty acids (SCFAs), colon length and index, and fecal moisture were increased, whereas colonic pH was decreased and defecation time was shortened. All of these changes were significantly different between polysaccharide-treated groups and the control group (p < 0.05). These findings suggested that an adequate intake of Dendronan is beneficial to the process of fermentation and regulation of colonic microenvironment, thus playing a role in the maintenance of colonic health.
本研究旨在探讨铁皮石斛多糖（Dendronan）对结肠健康的影响。分别以40、80和160mg/kg体重的剂量给小鼠喂食Dendronan，持续0、10、20和30天。结果表明，由甘露糖和葡萄糖形成特殊结构、富含O-乙酰基的Dendronan对Balb/c小鼠的结肠和粪便参数有改善作用。喂食Dendronan后，短链脂肪酸（SCFAs）含量、结肠长度和指数以及粪便水分增加，而结肠pH值降低，排便时间缩短。多糖处理组与对照组之间所有这些变化均有显著差异（p<0.05）。这些发现表明，适量摄入Dendronan有利于结肠发酵过程和微环境调节，从而在维持结肠健康中发挥作用。
