γ-氨基丁酸增加小鼠结肠中短链脂肪酸的产生并降低pH值。

Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon.

作者信息

Xie Min, Chen Hai-Hong, Nie Shao-Ping, Yin Jun-Yi, Xie Ming-Yong

机构信息

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.

出版信息

Molecules. 2017 Apr 20;22(4):653. doi: 10.3390/molecules22040653.

Gamma-Aminobutyric acid (GABA) could regulate physiological functions in the gastrointestinal tract. The present study aimed to investigate the effect of GABA on colon health in mice. The female Kunming mice were given GABA at doses of 5, 10, 20 and 40 mg/kg/d for 14 days. Afterwards, the short-chain fatty acids (SCFAs) concentrations, pH values, colon index, colon length and weight of colonic and cecal contents were determined to evaluate the effects of GABA on colon health. The results showed that intake of GABA could increase the concentrations of acetate, propionate, butyrate and total SCFAs in colonic and cecal contents, as well as the weight of colonic and cecal contents. The colon index and length of the 40 mg/kg/d GABA-treated group were significantly higher than those of the control group ( < 0.05). In addition, decrease of pH values in colonic and cecal contents was also observed. These results suggest that GABA may improve colon health.

γ-氨基丁酸（GABA）可调节胃肠道的生理功能。本研究旨在探讨GABA对小鼠结肠健康的影响。将雌性昆明小鼠分别给予5、10、20和40 mg/kg/d剂量的GABA，持续14天。之后，测定结肠和盲肠内容物的短链脂肪酸（SCFA）浓度、pH值、结肠指数、结肠长度以及重量，以评估GABA对结肠健康的影响。结果表明，摄入GABA可增加结肠和盲肠内容物中乙酸、丙酸、丁酸和总SCFA的浓度，以及结肠和盲肠内容物的重量。40 mg/kg/d GABA处理组的结肠指数和长度显著高于对照组（<0.05）。此外，还观察到结肠和盲肠内容物pH值降低。这些结果表明，GABA可能改善结肠健康。