Department of Cardiology, Pitié-Salpêtrière Hospital, University Pierre and Marie Curie and IHU ICAN, Paris, France
2nd Medical Department with Cardiology and Intensive Care Medicine, Rudolfstiftung Hospital, Vienna, Austria.
Eur Heart J. 2016 Jan 7;37(2):152-60. doi: 10.1093/eurheartj/ehv437. Epub 2015 Sep 1.
Chronic ischaemic cardiovascular disease (CICD) is a major cause of mortality and morbidity worldwide. The primary objective of the CICD-Pilot registry was to describe the clinical characteristics and management modalities across Europe in a broad spectrum of patients with CICD.
The CICD-Pilot registry is an international prospective observational longitudinal registry, conducted in 100 centres from 10 countries selected to reflect the diversity of health systems and care attitudes across Europe. From April 2013 to December 2014, 2420 consecutive CICD patients with non-ST-elevation acute coronary syndrome (n = 755) and chronic stable coronary artery disease (n = 1464), of whom 933 (63.7%) were planned for elective coronary intervention, or with peripheral artery disease (PAD) (n = 201), were enrolled (30.5% female patients). Mean age was 66.6 ± 10.9 years. The following risk factors were reported: smoking 54.6%, diabetes mellitus 29.2%, hypertension 82.6%, and hypercholesterolaemia 74.1%. Assessment of cardiac function was made in 69.5% and an exercise stress test in 21.2% during/within 1 year preceding admission. New stress imaging modalities were applied in a minority of patients. A marked increase was observed at discharge in the rate of prescription of angiotensin-converting enzyme-inhibitors/angiotensin receptor blockers (82.8%), beta-blockers (80.2%), statins (92.7%), aspirin (90.3%), and clopidogrel (66.8%). Marked differences in clinical profile and treatment modalities were observed across the four cohorts.
The CICD-Pilot registry suggests that implementation of guideline-recommended therapies has improved since the previous surveys but that important heterogeneity exists in the clinical profile and treatment modalities in the different cohorts of patients enrolled with a broad spectrum of CICDs.
慢性缺血性心血管疾病（CICD）是全球范围内死亡和发病的主要原因。CICD-Pilot 注册研究的主要目的是描述欧洲广泛的 CICD 患者的临床特征和管理模式。
CICD-Pilot 注册研究是一项国际性的前瞻性观察性纵向注册研究，在 10 个国家的 100 个中心进行，这些中心的选择反映了欧洲不同的卫生系统和护理态度。从 2013 年 4 月至 2014 年 12 月，共纳入 2420 例连续的 CICD 患者，包括非 ST 段抬高型急性冠状动脉综合征患者（n=755）和慢性稳定型冠状动脉疾病患者（n=1464），其中 933 例（63.7%）计划行择期冠状动脉介入治疗或外周动脉疾病患者（n=201）。患者平均年龄为 66.6±10.9 岁。报告的以下危险因素包括：吸烟 54.6%、糖尿病 29.2%、高血压 82.6%和高胆固醇血症 74.1%。69.5%的患者在入院前 1 年内进行了心脏功能评估，21.2%的患者进行了运动负荷试验。少数患者应用了新的应激成像方式。出院时，血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂（82.8%）、β受体阻滞剂（80.2%）、他汀类药物（92.7%）、阿司匹林（90.3%）和氯吡格雷（66.8%）的使用率显著增加。四个队列的临床特征和治疗方式存在明显差异。
CICD-Pilot 注册研究表明，自前次调查以来，指南推荐的治疗方法的实施有所改善，但在不同队列的 CICD 患者中，临床特征和治疗方式存在显著差异。
