川西小石积叶和嫩枝中的酚类化合物可抑制大鼠晶状体醛糖还原酶并使斑马鱼幼体血管扩张

Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae.

作者信息

Lee Ik-Soo, Jung Seung-Hyun, Lee Yun Mi, Choi So-Jin, Sun Hang, Kim Jin Sook

机构信息

KM Convergence Research Division, Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.

Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, Yunnan 650204, People's Republic of China.

出版信息

J Nat Prod. 2015 Sep 25;78(9):2249-54. doi: 10.1021/acs.jnatprod.5b00469. Epub 2015 Sep 2.

DOI:10.1021/acs.jnatprod.5b00469

PMID:26331986

Abstract

Three new phenolic biphenyl derivatives (1-3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1-4 on rat lens aldose reductase in vitro were examined, and compounds 1-3 markedly inhibited the enzyme with IC50 values of 3.8 to 13.8 μM. In addition, the effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in zebrafish larvae were investigated. Compound 1 was the most effective in reducing HG-induced dilation of hyaloid-retinal vessels.

摘要

从川西 osteomeles 的叶和嫩枝中分离出三种新的酚类联苯衍生物（1-3）和一种新的木脂素糖苷（4）。通过光谱数据解析确定了新化合物的结构。检测了 1-4 对大鼠晶状体醛糖还原酶的体外抑制作用，化合物 1-3 对该酶有显著抑制作用，IC50 值为 3.8 至 13.8 μM。此外，研究了这些分离物对高糖（HG）诱导的斑马鱼幼虫玻璃样视网膜血管扩张的影响。化合物 1 在减轻 HG 诱导的玻璃样视网膜血管扩张方面最有效。