Department of Paediatrics and Neonatology, Emma Children's Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.
Ecobaby Foundation, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands.
Int J Environ Res Public Health. 2018 Jun 27;15(7):1352. doi: 10.3390/ijerph15071352.
Dioxins (polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDF)), polychlorinated biphenyls (PCBs), and brominated flame retardants (BDEs) are well known toxic environmental contaminants. Their possible role in the incidence of respiratory disease is not yet well understood. Previous studies showed a negative effect on lung function in relation to prenatal and lactational dioxin exposure in pre-pubertal children. Effects of BDE exposure on the lung function have not previously been evaluated. As part of a longitudinal cohort study, the effects of perinatal dioxin (PCDD/F) exposure and serum PCDD/F, dl-PCB, and BDE levels on lung function in adolescents were assessed using spirometry, a body box, and diffusion measurements. Thirty-three children (born between 1986 and 1991) consented to the current follow-up study. Prenatal, lactational, and current dioxin, PCB, and BDE concentrations were determined using GC-MS. No relationship was seen between prenatal and lactational dioxin exposure, nor with current PCB body burden, and lung function. Indications of increasing airway obstruction were seen in relation to increasing current BDE exposure. This is a novel finding and certainly warrants further research.
二恶英（多氯二苯并对二恶英（PCDDs）和多氯二苯并呋喃（PCDFs））、多氯联苯（PCBs）和溴化阻燃剂（BDEs）是众所周知的有毒环境污染物。它们在呼吸道疾病发病中的可能作用尚未得到很好的理解。先前的研究表明，产前和哺乳期接触二恶英会对青春期前儿童的肺功能产生负面影响。先前尚未评估 BDE 暴露对肺功能的影响。作为一项纵向队列研究的一部分，使用肺活量计、体盒和扩散测量评估了围产期二恶英（PCDD/F）暴露和血清 PCDD/F、dl-PCB 和 BDE 水平对青少年肺功能的影响。33 名儿童（1986 年至 1991 年之间出生）同意进行当前的随访研究。使用 GC-MS 测定产前、哺乳期和当前的二恶英、多氯联苯和 BDE 浓度。产前和哺乳期二恶英暴露以及当前多氯联苯的身体负担与肺功能之间没有关系。与当前 BDE 暴露的增加相关，出现了气道阻塞增加的迹象。这是一个新的发现，肯定需要进一步研究。
