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脓肿分枝杆菌中诱导型克拉霉素耐药性的快速预测

Rapid prediction of inducible clarithromycin resistance in Mycobacterium abscessus.

作者信息

Zhu Yan Chun, Mitchell Kara K, Nazarian Elizabeth J, Escuyer Vincent E, Musser Kimberlee A

机构信息

Wadsworth Center, New York State Department of Health, Albany, NY, USA.

Wadsworth Center, New York State Department of Health, Albany, NY, USA.

出版信息

Mol Cell Probes. 2015 Dec;29(6):514-516. doi: 10.1016/j.mcp.2015.08.007. Epub 2015 Sep 1.

DOI:10.1016/j.mcp.2015.08.007
PMID:26334290
Abstract

We have developed a single tube TaqMan(®) real-time PCR assay that differentiates the full-length and truncated erm(41) gene to predict inducible resistance to clarithromycin in Mycobacterium abscessus. A study of 87 clinical isolates found this assay to be 90.8% concordant to conventional drug susceptibility testing results for the prediction of inducible clarithromycin drug resistance.

摘要

我们开发了一种单管TaqMan®实时荧光定量PCR检测方法，该方法可区分全长和截短的erm(41)基因，以预测脓肿分枝杆菌对克拉霉素的诱导性耐药性。对87株临床分离株的研究发现，该检测方法在预测克拉霉素诱导性耐药性方面与传统药敏试验结果的一致性为90.8%。

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Rapid prediction of inducible clarithromycin resistance in Mycobacterium abscessus.脓肿分枝杆菌中诱导型克拉霉素耐药性的快速预测
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A real-time PCR assay for rapid identification of inducible and acquired clarithromycin resistance in Mycobacterium abscessus.
实时 PCR 检测法快速鉴定脓肿分枝杆菌诱导型和获得型克拉霉素耐药性。
BMC Infect Dis. 2020 Dec 10;20(1):944. doi: 10.1186/s12879-020-05686-0.
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