Lee Seung Woo, Cheon Seon Ah, Kim Moon Il, Park Tae Jung
Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.
Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 461-701, Republic of Korea.
J Nanobiotechnology. 2015 Sep 4;13:54. doi: 10.1186/s12951-015-0118-0.
Organic-inorganic hybrid nanoflowers, a newly developed class of flower-like hybrid nanoparticles, have received much attention due to their simple synthesis, high efficiency, and enzyme stabilizing ability. This article covers, in detail, the types, structural features, mechanism of formation, and bio-related applications of hybrid nanoflowers. The five major types of hybrid nanoflowers are discussed, i.e., copper-protein, calcium-protein, and manganese-protein hybrid nanoflowers, copper-DNA hybrid nanoflowers, and capsular hybrid nanoflowers. The structural features of these nanoflowers, such as size, shape, and protein ratio generally determine their applications. Thus, the specific characteristics of hybrid nanoflowers are summarized in this review. The interfacial mechanism of nanoflower formation is examined in three steps: first, combination of metal ion and organic matter; second, formation of petals; third, growth of nanoflowers. The explanations provided herein can be utilized in the development of innovative approaches for the synthesis of hybrid nanoflowers for prospective development of a plethora of hybrid nanoflowers. The future prospects of hybrid nanoflowers in the biotechnology industry, medicine, sensing, and catalysis are also discussed.
有机-无机杂化纳米花是一类新开发的花状杂化纳米粒子，因其合成简单、效率高和具有酶稳定能力而备受关注。本文详细介绍了杂化纳米花的类型、结构特征、形成机制及其生物相关应用。文中讨论了五种主要类型的杂化纳米花，即铜-蛋白质、钙-蛋白质和锰-蛋白质杂化纳米花、铜-DNA杂化纳米花以及包膜杂化纳米花。这些纳米花的结构特征，如尺寸、形状和蛋白质比例，通常决定了它们的应用。因此，本综述总结了杂化纳米花的具体特性。纳米花形成的界面机制分三步进行研究：首先是金属离子与有机物的结合；其次是花瓣的形成；最后是纳米花的生长。本文提供的解释可用于开发创新方法来合成杂化纳米花，以促进大量杂化纳米花的未来发展。文中还讨论了杂化纳米花在生物技术产业、医学、传感和催化领域的未来前景。
