Ma Yan-Yan, Zhao Deng-Gao, Zhou Ai-Yu, Zhang Yu, Du Zhiyun, Zhang Kun
College of Light Industry and Chemical Engineering, Guangdong University of Technology , Guangzhou, Guangdong 510006, People's Republic of China.
School of Chemistry and Environment Engineering, Wuyi University , Jiangmen, Guangdong 529020, People's Republic of China.
J Agric Food Chem. 2015 Sep 23;63(37):8162-9. doi: 10.1021/acs.jafc.5b03081. Epub 2015 Sep 15.
The flowers of Edgeworthia gardneri are consumed as an herbal tea in Tibet with potential health benefits. To complement the current knowledge regarding the chemical composition and antihyperglycemic activity of the flower of E. gardneri, two new phenolics, gardnerol A and B (1 and 2), along with 19 known phenolics were isolated from the flower of E. gardneri. All isolates were evaluated for their inhibitory activity against α-glucosidase. Compound 5, identified as the major constituent of the flower of E. gardneri, showed a significant α-glucosidase inhibitory activity and acted as a competitive inhibitor. The oral administration of compound 5 at a dose of 300 mg/kg significantly reduced the postprandial blood glucose levels of normal and streptozotocin (STZ)-induced diabetic mice. Furthermore, compound 5 significantly decreased the fasting blood glucose levels in STZ-induced diabetic mice.
在西藏，结香花被用作花草茶饮用，可能对健康有益。为补充目前关于结香花化学成分和降血糖活性的知识，从结香花中分离出两种新的酚类化合物，结香酚A和B（1和2），以及19种已知的酚类化合物。评估了所有分离物对α-葡萄糖苷酶的抑制活性。化合物5被鉴定为结香花的主要成分，显示出显著的α-葡萄糖苷酶抑制活性，并作为竞争性抑制剂起作用。以300mg/kg的剂量口服化合物5可显著降低正常小鼠和链脲佐菌素（STZ）诱导的糖尿病小鼠的餐后血糖水平。此外，化合物5显著降低了STZ诱导的糖尿病小鼠的空腹血糖水平。
