Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany ; Contributed equally.
Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany ; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany.
J Clin Transl Hepatol. 2014 Mar;2(1):23-30. doi: 10.14218/JCTH.2013.00022. Epub 2014 Mar 15.
Proteomics has evolved into a powerful and widely used bioanalytical technique in the study of cancer, especially hepatocellular carcinoma (HCC). In this review, we provide an up to date overview of feasible proteome-analytical techniques for clinical questions. In addition, we present a broad summary of proteomic studies of HCC utilizing various technical approaches for the analysis of samples derived from diverse sources like HCC cell lines, animal models, human tissue and body fluids.
蛋白质组学已经发展成为癌症研究中一种强大且广泛应用的生物分析技术,尤其是在肝细胞癌(HCC)的研究中。在这篇综述中,我们提供了对可用于临床问题的可行蛋白质组分析技术的最新概述。此外,我们还广泛总结了利用各种技术方法对源自不同来源(如 HCC 细胞系、动物模型、人体组织和体液)的样本进行 HCC 蛋白质组学研究的情况。