Zhao Ying-Yong, Cheng Xian-Long, Lin Rui-Chao, Wei Feng
Key Laboratory of Resource Biology & Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Biomark Med. 2015;9(2):153-68. doi: 10.2217/bmm.14.81.
Lipidomics is a lipid-targeted metabolomics approach focusing on comprehensive analysis of all lipids with which they interact in biology systems. Recent technological advances in MS and chromatography have greatly enhanced the developments and applications of metabolic profiling of diverse lipids in complex biological samples. Lipidomics will not only provide insights into the specific functions of lipid species in health and disease, but will also identify potential biomarkers for establishing preventive or therapeutic programs for human disease. In this review, recent applications of lipidomics to understand animal models of disease such as metabolic syndromes, neurodegenerative diseases, cancer and infectious diseases are considered. We also discuss the lipidomics for the future perspectives and their potential problems.
脂质组学是一种以脂质为靶向的代谢组学方法，专注于对生物系统中与之相互作用的所有脂质进行全面分析。质谱和色谱技术的最新进展极大地推动了复杂生物样品中各种脂质代谢谱分析的发展与应用。脂质组学不仅将为脂质种类在健康和疾病中的特定功能提供见解，还将识别潜在的生物标志物，以建立人类疾病的预防或治疗方案。在这篇综述中，我们考虑了脂质组学在理解疾病动物模型（如代谢综合征、神经退行性疾病、癌症和传染病）方面的最新应用。我们还讨论了脂质组学的未来前景及其潜在问题。
