Department of Pediatrics, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan.
Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan.
Environ Pollut. 2015 Dec;207:145-51. doi: 10.1016/j.envpol.2015.08.044. Epub 2015 Sep 12.
Data concerning the effects of prenatal exposures to nonylphenol (NP) and oxidative stress on neonatal birth outcomes from human studies are limited. A total of 146 pregnant women were studied (1) to investigate the association between prenatal NP exposure and maternal oxidative/nitrative stress biomarkers of DNA damage (8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2Gua)) and lipid peroxidation (8-iso-prostaglandin F2α (8-isoPF2α), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)) and (2) to explore the associations among oxidative stress biomarkers, NP exposure, and neonatal birth outcomes, including gestational age, birth weight, length, Ponderal index, and head and chest circumferences. NP significantly increased the 8-OHdG and 8-NO2Gua levels. All infants born to mothers with urinary 8-OHdG levels above the median exhibited a significantly shorter gestational duration (Badjusted = -4.72 days; 95% CI: -8.08 to -1.36 days). No clear association was found between NP levels and birth outcomes. Prenatal 8-OHdG levels might be a novel biomarker for monitoring fetal health related to NP exposure.
关于人类研究中非那西丁（NP）暴露和氧化应激对新生儿出生结局影响的数据有限。共研究了 146 名孕妇：(1) 研究 NP 暴露与母体氧化/硝化应激生物标志物 DNA 损伤（8-羟基-2'-脱氧鸟苷（8-OHdG）、8-硝基鸟嘌呤（8-NO2Gua））和脂质过氧化（8-异前列腺素 F2α（8-isoPF2α）、4-羟基-2-壬烯醛-巯基尿酸（HNE-MA））之间的关系；(2) 探索氧化应激生物标志物、NP 暴露与新生儿出生结局（包括胎龄、出生体重、身长、体质量指数和头围、胸围）之间的关系。NP 显著增加了 8-OHdG 和 8-NO2Gua 的水平。所有母亲尿液 8-OHdG 水平高于中位数的婴儿胎龄明显缩短（调整后=-4.72 天；95%CI：-8.08 至-1.36 天）。NP 水平与出生结局之间无明显相关性。产前 8-OHdG 水平可能是监测与 NP 暴露相关的胎儿健康的新型生物标志物。
