Xi Bo, Li Shuangshuang, Liu Zhaolu, Tian Huan, Yin Xiuxiu, Huai Pengcheng, Tang Weihong, Zhou Donghao, Steffen Lyn M
Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan, China.
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China.
PLoS One. 2014 Mar 28;9(3):e93471. doi: 10.1371/journal.pone.0093471. eCollection 2014.
Several prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. In the present study, we aimed to estimate the association between fruit juice intake and risk of type 2 diabetes.
PubMed and Embase databases were searched up to December 2013. All prospective cohort studies of fruit juice intake with risk of type 2 diabetes were included. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for highest vs. lowest category of fruit juice intake were estimated using a random-effects model.
A total of four studies (191,686 participants, including 12,375 with type 2 diabetes) investigated the association between sugar-sweetened fruit juice and risk of incident type 2 diabetes, and four studies (137,663 participants and 4,906 cases) investigated the association between 100% fruit juice and risk of incident type 2 diabetes. A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes (RR = 1.28, 95%CI = 1.04-1.59, p = 0.02), while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes (RR = 1.03, 95% CI = 0.91-1.18, p = 0.62).
Our findings support dietary recommendations to limit sugar-sweetened beverages, such as fruit juice with added sugar, to prevent the development of type 2 diabetes.
已经开展了多项前瞻性研究来探讨果汁摄入量与2型糖尿病发病风险之间的关系，但结果不一。在本研究中，我们旨在评估果汁摄入量与2型糖尿病风险之间的关联。
检索截至2013年12月的PubMed和Embase数据库。纳入所有关于果汁摄入量与2型糖尿病风险的前瞻性队列研究。使用随机效应模型估计果汁摄入量最高组与最低组相比的合并相对风险（RRs）及其95%置信区间（CIs）。
共有四项研究（191,686名参与者，其中12,375名患有2型糖尿病）调查了含糖果汁与2型糖尿病发病风险之间的关联，四项研究（137,663名参与者和4,906例病例）调查了100%果汁与2型糖尿病发病风险之间的关联。较高的含糖果汁摄入量与2型糖尿病风险显著相关（RR = 1.28，95%CI = 1.04 - 1.59，p = 0.02），而100%果汁的摄入量与2型糖尿病发病风险无关（RR = 1.03，95%CI = 0.91 - 1.18，p = 0.62）。
我们的研究结果支持饮食建议，即限制含糖饮料（如添加糖的果汁）的摄入，以预防2型糖尿病的发生。
