鼻烟和药用尼古丁产品的感知健康风险。
Perceived Health Risks of Snus and Medicinal Nicotine Products.
作者信息
Hatsukami Dorothy K, Vogel R I, Severson Herb H, Jensen Joni A, O'Connor Richard J
机构信息
Department of Psychiatry, Tobacco Research Programs, University of Minnesota, Minneapolis, MN;
Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN;
出版信息
Nicotine Tob Res. 2016 May;18(5):794-800. doi: 10.1093/ntr/ntv200. Epub 2015 Sep 18.
INTRODUCTION
Perceived health risk (PHR) of a tobacco product may influence both uptake and continued use. In this study, we examined PHRs of snus and medicinal nicotine using the PHR scale and the relationship of PHR responses to use of these products in smokers seeking an alternative to smoking.
METHODS
Smokers were randomly assigned to snus or to medicinal nicotine for a period of 12 weeks and asked to only use the assigned product. The PHR scale involves rating the extent of perceived risk of a product for different diseases and was given at baseline and weeks 4 and 12 during treatment. Relationships between PHR scale scores and study attrition, compliance with only using the product, and continued use of the product after treatment were determined.
RESULTS
Response to the PHR scale showed no significant differences between the snus and medicinal nicotine for perceived risks for lung cancer, emphysema, and bronchitis. However, significant differences were observed for other cancers, heart disease, stroke and risk for addiction, particularly after product use, with higher scores among those assigned to snus. Scores on the PHR scale were not related to any of the trial outcome variables.
CONCLUSIONS
Among smokers seeking an alternative to smoking in a clinic setting, PHR of a product changes after product use but may not be related to product use patterns.
IMPLICATIONS
PHRs of snus or medicinal nicotine in smokers assigned to these products become more accurate after product use. PHR does not appear to be associated with patterns of product use; rather satisfaction with a product is a better indicator as to whether a smoker is compliant with only using the product or continues to use the product.
引言
烟草产品的感知健康风险（PHR）可能会影响其使用的开始和持续。在本研究中，我们使用PHR量表检查了口含烟和药用尼古丁的PHR，以及在寻求替代吸烟方法的吸烟者中PHR反应与这些产品使用之间的关系。
方法
吸烟者被随机分配使用口含烟或药用尼古丁，为期12周，并被要求仅使用分配的产品。PHR量表包括对产品针对不同疾病的感知风险程度进行评分，并在治疗的基线、第4周和第12周进行评估。确定了PHR量表得分与研究损耗、仅使用产品的依从性以及治疗后产品持续使用之间的关系。
结果
对于肺癌、肺气肿和支气管炎的感知风险，口含烟和药用尼古丁在PHR量表上的反应没有显著差异。然而，在其他癌症、心脏病、中风和成瘾风险方面观察到了显著差异，尤其是在使用产品后，使用口含烟的人得分更高。PHR量表得分与任何试验结果变量均无关。
结论
在临床环境中寻求替代吸烟方法的吸烟者中，产品使用后产品的PHR会发生变化，但可能与产品使用模式无关。
启示
分配使用这些产品的吸烟者中，口含烟或药用尼古丁的PHR在产品使用后变得更准确。PHR似乎与产品使用模式无关；相反，对产品的满意度是吸烟者是否仅依从使用产品或继续使用产品的更好指标。
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