Ferguson Lucas, Eckard Laura, Epperson William B, Long Li-Ping, Smith David, Huston Carla, Genova Suzanne, Webby Richard, Wan Xiu-Feng
Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, United States.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States.
Virology. 2015 Dec;486:28-34. doi: 10.1016/j.virol.2015.08.030. Epub 2015 Sep 18.
A new member of the Orthomyxoviridae family, influenza D virus (IDV), was first reported in swine in the Midwest region of the United States. This study aims to extend our knowledge on the IDV epidemiology and to determine the impact of bovine production systems on virus spread. A total of 15 isolates were recovered from surveillance of bovine herds in Mississippi, and two genetic clades of viruses co-circulated in the same herd. Serologic assessment from neonatal beef cattle showed 94% seropositive, and presumed maternal antibody levels were substantially lower in animals over six months of age. Active IDV transmission was shown to occur at locations where young, weaned, and comingled calves were maintained. Serological characterization of archived sera suggested that IDV has been circulating in the Mississippi cattle populations since at least 2004. Continuous surveillance is needed to monitor the evolution and epidemiology of IDV in the bovine population.
正黏病毒科的一个新成员——丁型流感病毒（IDV），首次在美国中西部地区的猪身上被报道。本研究旨在扩展我们对IDV流行病学的认识，并确定牛生产系统对病毒传播的影响。从密西西比州牛群监测中总共分离出15株病毒，两种遗传分支的病毒在同一牛群中共同传播。新生肉牛的血清学评估显示94%呈血清阳性，而6个月以上动物的假定母源抗体水平显著较低。研究表明，IDV的活跃传播发生在饲养断奶幼牛和混群小牛的场所。对存档血清的血清学特征分析表明，至少自2004年以来，IDV一直在密西西比州的牛群中传播。需要持续监测以监控IDV在牛群中的演变和流行病学情况。
