Białek J, Denys A, Kowalska M, Ciebiada I, Szydłowska T
Department of Medical Microbiology, Military Medical Academy, Lódź.
Arch Immunol Ther Exp (Warsz). 1989;37(3-4):421-30.
This paper is the continuation of earlier studies on the effect of the killed suspension of Corynebacterium parvum in influenza virus infected mice. Our investigation showed the normalized effect of these drugs on disturbed function of cell mediated immunity during experimental influenza infection especially in phagocytic and bactericidal activity of granulocytes. The present experiments concern the explanation of these infection mechanisms. Intraperitoneal injection of Corynebacterium parvum stimulated spleen index. Foot pad test is higher than in comparatively treated BCG group. The pathomorphological analysis of the spleen, thymus and peritoneal lymph nodes points out to the multiplication of multiple lymph nodes sinus cells. Generally, C. parvum possessed protective effect in experimental influenza infection. We tested the following parameters: phagocytic and bactericidal activity of granulocytes, liberation of leukocytes migration inhibition factor (LIF).
本文是对先前关于小棒状杆菌灭活悬液对流感病毒感染小鼠影响研究的延续。我们的研究表明，这些药物对实验性流感感染期间细胞介导免疫功能紊乱具有正常化作用，尤其是对粒细胞的吞噬和杀菌活性。目前的实验旨在解释这些感染机制。腹腔注射小棒状杆菌可刺激脾脏指数。足垫试验结果高于相对治疗的卡介苗组。对脾脏、胸腺和腹膜淋巴结的病理形态学分析表明多个淋巴结窦细胞增殖。总体而言，小棒状杆菌在实验性流感感染中具有保护作用。我们检测了以下参数：粒细胞的吞噬和杀菌活性、白细胞迁移抑制因子（LIF）的释放。
