Kowalska M, Szydłowska T, Denys A, Białek J
Department of Medical Microbiology, Military Medical Academy, Lódź.
Arch Immunol Ther Exp (Warsz). 1987;35(4):453-6.
In the paper the influence of viral, bacterial and mixed viral-bacterial infections on phagocytic activity of mouse peritoneal granulocytes was estimated. Granulocytes isolated on the 3rd, 6th, 9th and 14th day of infection were incubated for 1 h at 37 degrees C together with S. aureus 209P cultivated in the presence of 14C labelled glucose. The radioactivity of samples was measured in the scintillatory counter. The results were shown as phagocytic index of granulocytes. The obtained data point to the decrease of granulocyte phagocytic activity in mice infected with bacteria in the first period of infection. When mice were infected with non-adapted influenza virus the decrease of granulocyte phagocytic activity was observed in the late stage of infection. The infection with adapted virus as well as mixed infection led to the complete disfunction of granulocyte phagocytic activity.
在该论文中，评估了病毒、细菌以及病毒 - 细菌混合感染对小鼠腹膜粒细胞吞噬活性的影响。在感染的第3天、第6天、第9天和第14天分离出的粒细胞，于37摄氏度下与在含有14C标记葡萄糖的环境中培养的金黄色葡萄球菌209P一起孵育1小时。样品的放射性在闪烁计数器中进行测量。结果以粒细胞的吞噬指数表示。所获得的数据表明，在感染的第一阶段感染细菌的小鼠中，粒细胞吞噬活性降低。当小鼠感染非适应性流感病毒时，在感染后期观察到粒细胞吞噬活性降低。感染适应性病毒以及混合感染导致粒细胞吞噬活性完全丧失功能。
