腐殖酸-葡聚糖组合对实验性肝损伤的预防作用。
Prophylactic effects of humic acid-glucan combination against experimental liver injury.
作者信息
Vetvicka Vaclav, Garcia-Mina Jose Maria, Yvin Jean-Claude
机构信息
Department of Pathology, University of Louisville, Louisville, USA.
Department of Chemistry and Soil Chemistry, Agricultural Chemistry and Biology Group, University of Navarra, Spain.
出版信息
J Intercult Ethnopharmacol. 2015 Jul-Sep;4(3):249-55. doi: 10.5455/jice.20150519103113. Epub 2015 May 25.
AIM
Despite intensive research, liver diseases represent a significant health problem and current medicine does not offer a substance able to significantly inhibit the hepatotoxicity leading to various stages of liver disease. Based on our previously published studies showing the protective effects of a glucan-humic acid (HA) combination, we focused on the hypothesis that the combination of these two natural molecules can offer prophylactic protection against experimentally induced hepatotoxicity.
MATERIALS AND METHODS
Lipopolysaccharide, carbon tetrachloride, and ethanol were used to experimentally damage the liver. Levels of aspartate aminotransferase, alanine transaminase, alkaline phosphatase, glutathione, superoxide dismutase, and malondialdehyde, known to correspond to the liver damage, were assayed.
RESULTS
Using three different hepatotoxins, we found that in all cases, some samples of HA and most of all the glucan-HA combination, offer strong protection against liver damage.
CONCLUSION
Glucan-HA combination is a promising agent for use in liver protection.
目的
尽管进行了深入研究，但肝脏疾病仍是一个重大的健康问题，目前的医学尚未提供一种能够显著抑制导致肝脏疾病各个阶段的肝毒性的物质。基于我们之前发表的显示葡聚糖 - 腐殖酸（HA）组合具有保护作用的研究，我们聚焦于这一假设，即这两种天然分子的组合可以为实验性诱导的肝毒性提供预防性保护。
材料与方法
使用脂多糖、四氯化碳和乙醇对肝脏进行实验性损伤。检测了已知与肝损伤相关的天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、谷胱甘肽、超氧化物歧化酶和丙二醛的水平。
结果
使用三种不同的肝毒素，我们发现在所有情况下，一些腐殖酸样本以及尤其是葡聚糖 - 腐殖酸组合，对肝损伤提供了强大的保护作用。
结论
葡聚糖 - 腐殖酸组合是一种有前景的用于肝脏保护的药物。
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