Nakashima M
Endod Dent Traumatol. 1989 Dec;5(6):279-86. doi: 10.1111/j.1600-9657.1989.tb00374.x.
Implantation of autolyzed antigen-extracted allogeneic (AAA) dentin matrix gelatin powder caused homeoinduction on amputated dental pulps. This event began with migration of spindle-shaped mesenchymal cells into the cavity on the amputated pulp. This was followed by proliferation of undifferentiated large cells concomitantly with vascular invasion and attachment of spindle-shaped cells and large cells to the AAA dentin. The adhering cells differentiated into osteodentinoblasts and/or preodontoblasts to form osteodentin matrix and predentin respectively. Osteodentinocytes and odontoblasts, then, formed osteodentin and tubular dentin. The healing of pulp dressed with inactivated AAA dentin using guanidine HCl was delayed. These results suggested that AAA dentin matrix powder may have chemotactic and mitogenic activity for undifferentiated mesenchymal cells and may provide a suitable scaffolding for fixation of these cells. Compartments of microenvironment formed by AAA dentin and the enveloping hard substances may play some role in differentiation into odontoblasts.
自体溶解抗原提取的同种异体（AAA）牙本质基质明胶粉末植入可对切断的牙髓产生同源诱导作用。这一过程始于梭形间充质细胞迁移至切断牙髓的腔内。随后，未分化的大细胞增殖，同时血管侵入，梭形细胞和大细胞附着于AAA牙本质。附着的细胞分别分化为骨牙本质细胞和成牙本质前体细胞，形成骨牙本质基质和前期牙本质。然后，骨牙本质细胞和成牙本质细胞形成骨牙本质和管状牙本质。用盐酸胍灭活的AAA牙本质处理的牙髓愈合延迟。这些结果表明，AAA牙本质基质粉末可能对未分化的间充质细胞具有趋化和促有丝分裂活性，并可能为这些细胞的固定提供合适的支架。由AAA牙本质和周围硬物质形成的微环境隔室可能在向成牙本质细胞的分化中发挥一定作用。
