Nakashima M
Department of Conservative Dentistry, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
Arch Oral Biol. 1990;35(7):493-7. doi: 10.1016/0003-9969(90)90078-o.
Reparative dentine was formed in the cavity of the amputated pulp when capped with crude allogeneic BMP. This began with a slight cell-mediated immune response and was followed by resorption of BMP and proliferation of migratory spindle-shaped mesenchymal cells, together with vascular invasion. Four weeks postoperatively, there were osteodentinoblasts embedded in forming matrix and/or osteodentinocytes trapped within osteodentine in some parts of the cavity. Other parts were filled with pulpal tissue. Eight weeks postoperatively, odontoblasts were forming tubular dentine next to the osteodentine. In albumin-implanted controls, a little osteodentine and no tubular dentine were seen. These findings suggest that dissolved BMP stimulates mitosis of mesenchymal cells and may induce differentiation of osteodentinocytes. The resultant osteodentine may play some role in the differentiation of odontoblasts.
当用粗制同种异体骨形态发生蛋白（BMP）覆盖切断的牙髓腔时，可形成修复性牙本质。这始于轻微的细胞介导免疫反应，随后是BMP的吸收以及游走的梭形间充质细胞的增殖，并伴有血管侵入。术后四周，在腔的某些部位有包埋于正在形成的基质中的成骨牙本质细胞和/或被困在骨样牙本质内的成骨牙本质细胞。其他部位充满了牙髓组织。术后八周，成牙本质细胞在骨样牙本质旁形成管状牙本质。在植入白蛋白的对照组中，可见少量骨样牙本质，未见管状牙本质。这些发现表明，溶解的BMP刺激间充质细胞的有丝分裂，并可能诱导成骨牙本质细胞的分化。所形成的骨样牙本质可能在成牙本质细胞的分化中起一定作用。
