Zhao Xu-Yun, Lin Jiandie D
Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Trends Biochem Sci. 2015 Oct;40(10):586-596. doi: 10.1016/j.tibs.2015.08.002.
Long noncoding RNAs (lncRNAs) are emerging as an integral part of the regulatory information encoded in the genome. lncRNAs possess the unique capability to interact with nucleic acids and proteins, and exert discrete effects on numerous biological processes. Recent studies have delineated multiple lncRNA pathways that control metabolic tissue development and function. The expansion of the regulatory code that links nutrient and hormonal signals to tissue metabolism gives new insights into the genetic and pathogenic mechanisms underlying metabolic disease. This review discusses lncRNA biology with a focus on their role in the development, signaling, and function of key metabolic tissues.
长链非编码RNA（lncRNAs）正逐渐成为基因组中编码的调控信息不可或缺的一部分。lncRNAs具有与核酸和蛋白质相互作用的独特能力，并对众多生物学过程产生离散效应。最近的研究已经描绘出多条控制代谢组织发育和功能的lncRNA途径。将营养和激素信号与组织代谢联系起来的调控密码的扩展，为深入了解代谢性疾病的遗传和致病机制提供了新的见解。本综述讨论了lncRNA生物学，重点关注它们在关键代谢组织的发育、信号传导和功能中的作用。
