参与预防母婴传播项目的HIV阳性母亲所生婴儿出生时的血液学指标
Hematological Indices at Birth of Infants of HIV-Positive Mothers Participating in a Prevention of Mother-to-Child Transmission Program.
作者信息
Obumneme-Anyim Ijeoma, Ibeziako Ngozi, Emodi Ifeoma, Ikefuna Anthony, Oguonu Tagbo
机构信息
Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla Enugu, 402139, Nigeria, Enugu Campus,
Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla Enugu, 402139, Nigeria, Enugu Campus.
出版信息
J Trop Pediatr. 2016 Feb;62(1):3-9. doi: 10.1093/tropej/fmv061. Epub 2015 Sep 27.
BACKGROUND
The mother-to-child transmission of HIV, which accounts for 90% of infections in children, has been reduced markedly through the use of antiretroviral drugs by pregnant women and their newborns. Changes to the World Health Organization guidelines support further extension of the prevention of mother-to-child transmission programs with increased risk of toxicity on the fetuses.
AIM
To determine the hematological indices at birth of infants exposed in utero to maternal antiretroviral drugs.
METHOD
A comparative analytical study of 126 neonates whose blood samples were analyzed to determine their hematological indices.
RESULT
The hemoglobin, hematocrit, the total white blood cell (WBC) count and absolute neutrophil count (ANC) were significantly lower in infants of HIV-positive mothers. The total WBC and ANC were also significantly lower in the highly active antiretroviral therapy. HAART group and those exposed to maternal drugs for <1 year.
CONCLUSION
There are significant changes in the hematological indices of infants of HIV-positive mothers at birth.
背景
母婴传播的艾滋病病毒占儿童感染的90%，通过孕妇及其新生儿使用抗逆转录病毒药物，这一传播率已显著降低。世界卫生组织指南的修订支持进一步扩大母婴传播预防项目，但这会增加对胎儿的毒性风险。
目的
确定子宫内接触母体抗逆转录病毒药物的婴儿出生时的血液学指标。
方法
对126名新生儿进行比较分析研究，分析其血样以确定血液学指标。
结果
感染艾滋病毒母亲的婴儿血红蛋白、血细胞比容、白细胞（WBC）总数和绝对中性粒细胞计数（ANC）显著较低。在高效抗逆转录病毒治疗（HAART）组以及接触母体药物<1年的婴儿中，白细胞总数和绝对中性粒细胞计数也显著较低。
结论
感染艾滋病毒母亲的婴儿出生时血液学指标有显著变化。
Zotero 插件