Lao Yi, Law Meng, Shi Jie, Gajawelli Niharika, Haas Lauren, Wang Yalin, Leporé Natasha
Department of Radiology, Children's Hospital Los Angeles, Los Angeles CA, USA ; Department of Biomedical Engineering, University of Southern California, Los Angeles CA, USA.
Department of Biomedical Engineering, University of Southern California, Los Angeles CA, USA ; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Proc SPIE Int Soc Opt Eng. 2015 Jan 28;9287. doi: 10.1117/12.2072600.
Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes. Here, for the first time, we fuse T1 surface-based morphometry and a new DTI analysis on 3D surface representations of the CCs into a single statistical analysis on these subjects. Our new combined method successfully increases detection power in detecting differences between pre- vs. post-season contact sports players. Alterations are found in the ventral genu, isthmus, and splenium of CC. Our findings may inform future health assessments in contact sports players. The new method here is also the first truly multimodal diffusion and T1-weighted analysis of the CC in TBI, and may be useful to detect anatomical changes in the corpus callosum in other multimodal datasets.
与运动相关的创伤性脑损伤（TBI）是一个全球性的公共卫生问题，胼胝体（CC）损伤一直被视为TBI的一个重要指标。然而，即使在没有诊断出脑震荡的情况下，接触性运动运动员在一个赛季中头部也会遭受反复撞击，而关于这些撞击对胼胝体解剖结构的影响却知之甚少。此外，以往对T1加权和扩散张量脑磁共振图像（DTI）是分别进行分析的，但对这两种数据进行联合分析可能会提高统计功效，并能更全面地了解这些运动员亚临床脑震荡的解剖学相关性。在此，我们首次将基于T1表面的形态测量学和对胼胝体三维表面表示的新DTI分析融合到对这些受试者的单一统计分析中。我们新的组合方法成功提高了检测赛季前与赛季后接触性运动运动员之间差异的能力。在胼胝体的腹侧膝部、峡部和压部发现了变化。我们的研究结果可能为接触性运动运动员未来的健康评估提供参考。这里的新方法也是首次对TBI中的胼胝体进行真正的多模态扩散和T1加权分析，可能有助于检测其他多模态数据集中胼胝体的解剖学变化。
