Fashi Mohamad, Agha Alinejad Hamid, Asilian Mahabadi Hasan
Department of Physical Education and Sports Sciences, Tarbiat Modares University, Tehran, IR Iran.
Deptartment of Occupational Health Engineering, Tarbiat Modares University, Tehran, IR Iran.
Iran J Cancer Prev. 2015 May;8(3):e2333. doi: 10.17795/ijcp2333. Epub 2015 May 22.
Exposure to Air pollution PM10 results in lung inflammation increased risk of lung cancer. Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the pulmonary response to PM10 have not been investigated.
The present study evaluated the effect of aerobic exercise on the lung inflammatory and risk of lung cancer of rat exposed to PM10 carbon black.
Twenty four adult male Wistar rats were divided into 4 groups: A: control (without exposure PM10 and aerobic exercise; n = 6), B: aerobic exercise (five times per week for 4 weeks; n = 6), C: exposure to PM10 carbon black (5 mg/m(3); per rat; n = 6), D: and aerobic exercise concomitantly with exposure to PM10 carbon black (n = 6). The gene expression of TLR4, NF-κB and TNF-α were analyzed in lung tissue by Real time-PCR. In order to determine the significant differences between groups, one way ANOVA and LSD post hoc and Kruskal-Vallis test were used.
Aerobic exercise inhibited the PM10 -induced increase in the gene expression of TLR4, NF-κB and TNF-α. But there was significant different only between B and C groups for TNF-α and NF-κB (P = 0.047, 0.014, respectively).
We conclude that four week aerobic exercise presents protective effects in a rat model of PM10 carbon black-induced lung inflammation and risk of lung cancer. Our results indicate a need for human studies that evaluate the lung Responses to aerobic exercise chronically performed in polluted areas.
暴露于空气污染细颗粒物（PM10）会导致肺部炎症，增加患肺癌的风险。规律的有氧运动可改善不同肺部疾病的炎症状态。然而，长期有氧运动对肺部对PM10反应的影响尚未得到研究。
本研究评估有氧运动对暴露于PM10炭黑的大鼠肺部炎症和肺癌风险的影响。
将24只成年雄性Wistar大鼠分为4组：A组：对照组（不暴露于PM10且不进行有氧运动；n = 6），B组：有氧运动组（每周5次，共4周；n = 6），C组：暴露于PM10炭黑组（5毫克/立方米；每只大鼠；n = 6），D组：有氧运动并同时暴露于PM10炭黑组（n = 6）。通过实时聚合酶链反应分析肺组织中Toll样受体4（TLR4）、核因子κB（NF-κB）和肿瘤坏死因子-α（TNF-α）的基因表达。为确定组间的显著差异，采用单因素方差分析、最小显著差法（LSD）事后检验和Kruskal-Wallis检验。
有氧运动抑制了PM10诱导的TLR4、NF-κB和TNF-α基因表达增加。但仅B组和C组之间TNF-α和NF-κB存在显著差异（分别为P = 0.047、0.014）。
我们得出结论，四周的有氧运动对PM10炭黑诱导的肺部炎症和肺癌风险的大鼠模型具有保护作用。我们的结果表明需要进行人体研究，以评估在污染地区长期进行有氧运动对肺部的反应。
