暴露于空气污染会增加患鼻咽癌的风险。
Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution.
机构信息
Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.
Department of Pediatrics, Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.
出版信息
PLoS One. 2018 Sep 28;13(9):e0204568. doi: 10.1371/journal.pone.0204568. eCollection 2018.
BACKGROUND
Nasopharyngeal carcinoma (NPC) is a race-specific malignancy. The nasal cavity is the main entry point for air pollutants or poisonous gases into the human body. However, the risk of NPC in populations exposed to air pollution remains unknown.
METHODS
We combined data from the Taiwan Air Quality Monitoring Database (TAQMD) and the Longitudinal Health Insurance Database (LHID) to assess the risk of NPC in a population exposed to air pollution.
RESULTS
Multivariate analysis revealed positive trends for the association between the risk of NPC and exposure to air pollution. After adjusting for potential covariates, the risk of developing NPC increased with the increase in nitrogen dioxide (NO2) and fine particulate matter (PM2.5) exposure concentrations from 1.39 to 2.28 and 2.01 to 1.97, respectively, compared to the risks at the lowest concentration levels.
CONCLUSIONS
We identified a significant risk of NPC in a population exposed to air pollution. However, this study had several limitations. Moreover, additional experimental and clinical studies on the associations between environmental factors and NPC risk are warranted.
背景
鼻咽癌（NPC）是一种种族特异性恶性肿瘤。鼻腔是空气污染物或有毒气体进入人体的主要入口。然而，暴露于空气污染人群中 NPC 的风险尚不清楚。
方法
我们结合了来自台湾空气质量监测数据库（TAQMD）和长期健康保险数据库（LHID）的数据，以评估暴露于空气污染人群中 NPC 的风险。
结果
多变量分析显示 NPC 风险与空气污染暴露之间存在正相关趋势。在调整了潜在的混杂因素后，与最低浓度水平相比，NO2 和 PM2.5 暴露浓度分别从 1.39 增加到 2.28 和从 2.01 增加到 1.97 时，NPC 发病风险分别增加了 1.39 倍和 2.01 倍。
结论
我们发现暴露于空气污染的人群中 NPC 的风险显著增加。然而，本研究存在一些局限性。此外，有必要进行更多的环境因素与 NPC 风险之间关联的实验和临床研究。
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