Simon Nicolai, Stieglitz Thomas, Bucher Volker
Institute for MicroSystems Technology (iMST), Faculty of Mechanical & Medical Engineering, Furtwangen University, D-78120, Furtwangen im Schwarzwald, Germany.
Laboratory for Biomedical Microtechnology, Dept. Microsystems Eng.-IMTEK, University of Freiburg, D-79110, Freiburg, Germany.
Adv Healthc Mater. 2025 Feb;14(4):e2403149. doi: 10.1002/adhm.202403149. Epub 2024 Dec 26.
Area-selective atomic layer deposition (ASD) is a bottom-up process that is of particular importance in the semiconductor industry, as it prevents edge defects and avoids cost-intensive lithography steps. This approach not only offers immense potential for the manufacture of active implants but can also be used to improve them. This review paper presents various processes that can be used for this purpose. It also identifies aspects that shall be considered when implementing such a process for medical applications. For example, the inherent selectivity can be used to produce new biosensors, the passivated ASD can be used to encapsulate polymer-based implants, and the activated ASD can be used to improve electrode performance. Finally, the aspects that shall be considered in a coating for active implants are highlighted. ASD therefore offers great potential for use on active implants.
区域选择性原子层沉积(ASD)是一种自下而上的工艺,在半导体行业中尤为重要,因为它可以防止边缘缺陷并避免成本高昂的光刻步骤。这种方法不仅为有源植入物的制造提供了巨大潜力,还可用于改进有源植入物。本文综述了可用于此目的的各种工艺。它还确定了在将这种工艺应用于医疗应用时应考虑的方面。例如,固有选择性可用于生产新型生物传感器,钝化的ASD可用于封装基于聚合物的植入物,而活化的ASD可用于改善电极性能。最后,强调了在有源植入物涂层中应考虑的方面。因此,ASD在有源植入物上具有巨大的应用潜力。