Isawa T, Teshima T, Hirano T, Ebina A, Motomiya M, Konno K
J Nucl Med. 1984 Apr;25(4):447-54.
Using radioaerosol inhalation lung cinescintigraphy, pulmonary clearance mechanisms were studied in 21 patients with obstructive airways disease. In none of them did we find homogeneous deposition of inhaled radioaerosol in the lungs, or a steady, constant, axial, and cephalad transport of radioactivity in the major airways. Of the 21 patients, 14 showed temporary but frequent stopping and starting of radioactivity in the airways in the course of lung clearance; in ten there was reversal of flow; in five migration of radioactivity from one bronchus into the opposite, bypassing the trachea and often followed by shuttling between right and left bronchi; and in four there was spiral or zigzag transport of radioactivity. The overall lung retention ratio in the first 2 hr was not abnormal, but the airway deposition ratio was significantly above normal, and airway clearance efficiency was below. The alveolar deposition ratio was also significantly smaller in these patients.
利用放射性气溶胶吸入肺动态闪烁显像技术，对21例阻塞性气道疾病患者的肺清除机制进行了研究。在这些患者中，我们均未发现吸入的放射性气溶胶在肺内均匀沉积，也未发现放射性物质在主气道内呈稳定、恒定、轴向且向头侧的传输。21例患者中，14例在肺清除过程中气道内放射性出现暂时但频繁的停滞和启动；10例出现气流逆转；5例放射性物质从一个支气管进入对侧支气管，绕过气管，且常随后在左右支气管之间穿梭；4例出现放射性物质呈螺旋状或锯齿状传输。前2小时的总体肺滞留率并无异常，但气道沉积率显著高于正常，气道清除效率则低于正常。这些患者的肺泡沉积率也显著降低。
