Xiao Kai-Jun, Wang Wen-Xia, Dai Jia-Li, Zhu Liang
College of Food and Bioengineering, South China University of Technology, Wushan Road 381, Guangzhou 510641, China.
EXCLI J. 2014 Jul 18;13:782-91. eCollection 2014.
Many species from Senecio genus have been used in traditional medicine, and their pharmacological activities have been demonstrated. This study investigated the chemical composition and anti-inflammatory activities of essential oils from Senecio flammeus. A total of 48 components representing 98.41 % of the total oils were identified. The main compounds in the oils were α-farnesene (11.26 %), caryophyllene (8.69 %), n-hexadecanoic acid (7.23 %), and α-pinene (6.36 %). The anti-inflammatory activity of the essential oils was evaluated in rodents (10-90 mg/kg bw) in classical models of inflammation [carrageenan-induced paw edema, 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ear edema, and cotton pellet-induced granuloma]. The essential oils at doses of 10, 30, and 90 mg/kg bw significantly reduced carrageenan-induced paw edema by 17.42 % (P < 0.05), 52.90 % (P < 0.05), and 66.45 % (P < 0.05) 4 h after carrageenan injection, respectively, and significantly reduced myeloperoxidase activity (P < 0.05). The essential oils (10, 30, and 90 mg/kg) also produced a significant dose-dependent response to reduce TPA-induced ear edema by 20.27 % (P < 0.05), 33.06 % (P < 0.05), and 53.90 % (P < 0.05), respectively. The essential oils produced significant dose-response anti-inflammatory activity against cotton pellet-induced granuloma that peaked at the highest dose of 90 mg/kg (49.08 % wet weight and 47.29 % dry weight). Results demonstrate that the essential oils of S. flammeus were effective in the treatment of both acute and chronic inflammatory conditions, thereby supporting the traditional use of this herb.
许多千里光属物种已被用于传统医学，并且其药理活性也已得到证实。本研究调查了火焰千里光精油的化学成分和抗炎活性。共鉴定出48种成分，占总精油的98.41%。精油中的主要化合物为α-法呢烯（11.26%）、石竹烯（8.69%）、正十六烷酸（7.23%）和α-蒎烯（6.36%）。在啮齿动物（10 - 90 mg/kg体重）中，利用经典炎症模型[角叉菜胶诱导的爪肿胀、12 - O - 十四酰佛波醇 - 13 - 乙酸酯（TPA）诱导的耳肿胀和棉球诱导的肉芽肿]评估了精油的抗炎活性。在注射角叉菜胶4小时后，10、30和90 mg/kg体重剂量的精油分别使角叉菜胶诱导的爪肿胀显著降低了17.42%（P < 0.05）、52.90%（P < 0.05）和66.45%（P < 0.05），并显著降低了髓过氧化物酶活性（P < 0.05）。精油（10、30和90 mg/kg）对TPA诱导的耳肿胀也产生了显著的剂量依赖性反应，分别降低了20.27%（P < 0.05）、33.06%（P < 0.05）和53.90%（P < 0.05）。精油对棉球诱导的肉芽肿产生了显著的剂量反应性抗炎活性，在最高剂量90 mg/kg时达到峰值（湿重减少49.08%，干重减少47.29%）。结果表明，火焰千里光精油在治疗急性和慢性炎症方面均有效，从而支持了这种草药的传统用途。
