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苦瓜果实提取物对1型糖尿病大鼠血管并发症的影响。

Effect of Momordica charantia fruit extract on vascular complication in type 1 diabetic rats.

作者信息

Abas Razif, Othman Faizah, Thent Zar Chi

机构信息

Department of Anatomy, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor.

Department of Anatomy, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Malaysia.

出版信息

EXCLI J. 2015 Jan 30;14:179-89. doi: 10.17179/excli2014-539. eCollection 2015.

DOI:10.17179/excli2014-539
PMID:26417358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4553902/
Abstract

Diabetes mellitus is one of the risk factors in the development of vascular complications. Decreased nitric oxide (NO) production and increased lipid peroxidation in diabetes mellitus are the dominant exaggerating factors. Mormodica charantia (MC) was proven to be useful in improving diabetes mellitus and its complications. In the present study, a total of 40 male Sprague-Dawley rats were used. Diabetes was induced by a single dose (50 mg/kg) of streptozotocin (STZ), intramuscularly. Following 4 weeks of STZ induction, the animals were equally divided into five groups (n = 8); Control group (Ctrl), control group treated with MC (Ctrl-MC), diabetic untreated group (DM-Ctrl), diabetic group treated with MC (DM-MC) and diabetic group treated with metformin 150 g/kg (DM-Met). Oral administration of the MC fruit extract (1.5 g/kg) was continued for 28 days. DM-MC group showed a significant decrease (P < 0.05) in blood pressure, total cholesterol and triglyceride levels compared to the DM-Ctrl group. Aortic tissue NO level was significantly increased and malondialdehyde level was decreased in the DM-MC group. Immunohistochemical staining showed an increase in eNOS expression in the endothelial lining of the DM-MC group. Similarly, morphological deterioration of the aortic tissues was reverted to normal. In summary, treatment with the MC fruit extract exerted the significant vasculoprotective effect in the type 1 diabetic rat model.

摘要

糖尿病是血管并发症发生的危险因素之一。糖尿病患者体内一氧化氮（NO）生成减少和脂质过氧化增加是主要的加重因素。苦瓜已被证明对改善糖尿病及其并发症有效。在本研究中，共使用了40只雄性Sprague-Dawley大鼠。通过单次肌肉注射链脲佐菌素（STZ，50 mg/kg）诱导糖尿病。STZ诱导4周后，将动物平均分为五组（n = 8）；对照组（Ctrl）、用苦瓜处理的对照组（Ctrl-MC）、未治疗的糖尿病组（DM-Ctrl）、用苦瓜处理的糖尿病组（DM-MC）和用150 g/kg二甲双胍处理的糖尿病组（DM-Met）。持续28天口服苦瓜果实提取物（1.5 g/kg）。与DM-Ctrl组相比，DM-MC组的血压、总胆固醇和甘油三酯水平显著降低（P < 0.05）。DM-MC组主动脉组织的NO水平显著升高，丙二醛水平降低。免疫组织化学染色显示DM-MC组内皮细胞中内皮型一氧化氮合酶（eNOS）表达增加。同样，主动脉组织的形态学恶化恢复正常。总之，苦瓜果实提取物治疗对1型糖尿病大鼠模型具有显著的血管保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/6d341af07faf/EXCLI-14-179-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/70e002118d3f/EXCLI-14-179-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/86d71a4ac708/EXCLI-14-179-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/3bee5506498f/EXCLI-14-179-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/a53e5fb66884/EXCLI-14-179-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/27d9d3120af3/EXCLI-14-179-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/55e74efb42fc/EXCLI-14-179-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/f6e730ba896a/EXCLI-14-179-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/6d341af07faf/EXCLI-14-179-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/70e002118d3f/EXCLI-14-179-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/86d71a4ac708/EXCLI-14-179-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/3bee5506498f/EXCLI-14-179-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/a53e5fb66884/EXCLI-14-179-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/27d9d3120af3/EXCLI-14-179-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/55e74efb42fc/EXCLI-14-179-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/f6e730ba896a/EXCLI-14-179-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15fd/4553902/6d341af07faf/EXCLI-14-179-g-006.jpg

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