Kardaszewicz E, Machalski M, Woszczyk D, Woszczyk M, Harbut-Gryłka A
Pol Tyg Lek. 1989;44(30-31):721-3.
Genetic predisposition and environmental factors (physical, chemical, hormonal and drugs inducing collagen-like syndrome) play an important role in the pathogenesis of the systemic lupus erythematosus. Elimination of these factors from the environment of the genetically predisposed individuals may prevent part of them against the disease. Basing on the above assumption, a chart of prophylaxis has been constructed and distributed among the mothers with the systemic lupus erythematosus, recommending prophylactic measures in both mothers and children. Within 1977-1987, 50 children were examined from time to time. Basic laboratory tests, phenomenon LE, antinuclear antibodies and antibodies anti-DNA have been determined. Transient presence of antinuclear antibodies was seen in 23 children. A tendency to an increase in the antibody titre was observed in girls of this group whereas a decrease in the titre was noted in the boys with the time lapse. Systemic lupus erythematosus prophylaxis in both mothers and children is uncomplicated and favourable for children. Regular determination of antibodies enables early diagnosis of the disease.
遗传易感性和环境因素（物理、化学、激素及诱发胶原样综合征的药物）在系统性红斑狼疮的发病机制中起重要作用。从遗传易感个体的环境中消除这些因素可能会使其中一部分人预防该病。基于上述假设，已制定了一份预防图表并分发给患有系统性红斑狼疮的母亲，建议母亲和儿童采取预防措施。在1977年至1987年期间，对50名儿童进行了定期检查。测定了基本实验室检查、狼疮现象、抗核抗体和抗DNA抗体。23名儿童中发现了抗核抗体的短暂存在。在该组女孩中观察到抗体滴度有升高趋势，而随着时间推移，男孩的抗体滴度则有所下降。对母亲和儿童进行系统性红斑狼疮预防并不复杂，且对儿童有利。定期检测抗体能够实现疾病的早期诊断。
