Wang Li, Lu Kai, Li Jianchao, Sheng Li, Ding Rongjing, Hu Dayi
Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
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Zhonghua Xin Xue Guan Bing Za Zhi. 2015 May;43(5):428-31.
To analyze the value of 2- and 9-question patient health questionnaires (PHQ-2 and PHQ-9) for screening status of depression in cardiovascular outpatients.
From June 2013 to January 2014, a total of 201 outpatients from psycho-cardiological outpatients departments were consecutively enrolled into this study. All patients were asked to complete PHQ-9 and the mental psychological assessment by qualified researchers trained by psychiatry according to the composite international diagnostic interviews (CIDI), 50 cases were retested to assess the retest reliability after one week. The PHQ-2 and PHQ-9 were validated with the CIDI as the reference criteria.
According to the CIDI, 42 (21.3%) out of the 201 outpatients were diagnosed as depression. For PHQ-9 scale, a cutoff value of 10 presented satisfactory results with 87.1% sensitivity, 83.5% specificity, 58.7% positive predicting value, 95.6% negative predicting value and the area under the ROC curve (AUC) was 0.877 (SE = 0.032, 95% CI: 0.813-0.938). The Cronbach's alpha coefficients and test-retest reliability of the PHQ-9 were 0.809 and 0.882, respectively. Compared with CIDI, the cutoff value of the PHQ-2 was 3 with 85.7% sensitivity, 69.2% specificity, 57.1% positive predicting value, 93.6% negative predicting value, and the AUC was 0.806 (SE = 0.042, 95% CI: 0.774-0.889). The Cronbach's alpha coefficients and test-retest reliability of the PHQ-2 were 0.785 and 0.813, respectively.
The PHQ-2 and PHQ-9 are reliable and efficient instruments for screening and especially excluding depression in cardiovascular outpatients.
分析两题版和九题版患者健康问卷（PHQ - 2和PHQ - 9）在筛查心血管门诊患者抑郁状态方面的价值。
2013年6月至2014年1月，共有201名来自心血管精神科门诊的患者连续纳入本研究。所有患者均被要求完成PHQ - 9以及由接受过精神病学培训的合格研究人员根据复合国际诊断访谈（CIDI）进行的心理评估，其中50例患者在一周后进行复测以评估重测信度。以CIDI作为参考标准对PHQ - 2和PHQ - 9进行验证。
根据CIDI，201名门诊患者中有42例（21.3%）被诊断为抑郁。对于PHQ - 9量表，截断值为10时结果令人满意，灵敏度为87.1%，特异度为83.5%，阳性预测值为58.7%，阴性预测值为95.6%，ROC曲线下面积（AUC）为0.877（SE = 0.032，95% CI：0.813 - 0.938）。PHQ - 9的Cronbach's α系数和重测信度分别为0.809和0.882。与CIDI相比，PHQ - 2的截断值为3，灵敏度为85.7%，特异度为69.2%，阳性预测值为57.1%，阴性预测值为93.6%，AUC为0.806（SE = 0.042，95% CI：0.774 - 0.889）。PHQ - 2的Cronbach's α系数和重测信度分别为0.785和0.813。
PHQ - 2和PHQ - 9是用于筛查尤其是排除心血管门诊患者抑郁的可靠且有效的工具。
