Szatmári Tünde, Ötvös Rita, Hjerpe Anders, Dobra Katalin
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.
Dis Markers. 2015;2015:796052. doi: 10.1155/2015/796052. Epub 2015 Sep 1.
Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types.
Syndecan-1是一种细胞表面硫酸乙酰肝素蛋白聚糖，在多种肿瘤的分化和预后中起着关键作用。在本综述中，我们重点介绍了Syndecan-1的合成、细胞相互作用以及受其调节的信号通路。Syndecan-1的基础水平对于理解涉及恶性转化、肿瘤进展以及晚期或播散性癌症阶段的一系列变化也至关重要。此外，我们关注这种蛋白聚糖的细胞定位，即作为细胞膜锚定和/或脱落的、可溶性的Syndecan-1，以及其在基质或细胞核中的积累情况，以及这如何可能为个体肿瘤类型携带不同的、高度组织特异性的预后信息。
